Singh K, Flood J, Welsh R D, Wyckoff J H, Snider T A, Sutton D A
Department of Veterinary Pathobiology, McElroy Hall 250, Oklahoma State University, Stillwater, Oklahoma 74078-2007, USA.
Vet Pathol. 2006 Nov;43(6):988-92. doi: 10.1354/vp.43-6-988.
A 5-year-old Shetland Sheepdog was presented with a history of weakness, ataxia, anemia, thrombocytopenia, and occasional seizures. The dog had been treated for 6 months with prednisone for inflammatory bowel disease. A positive titer for Ehrlichia canis was detected 6 months before referral. The initial physical examination revealed a weak, laterally recumbent dog with pale mucous membranes. Neurologic examination revealed multiple neurologic deficits. A complete blood cell count (CBC) revealed normochromic, normocytic, nonregenerative anemia; lymphopenia; thrombocytopenia; and neutrophilic and monocytic leukocytosis. Urinalysis revealed proteinuria, with a specific gravity of 1.045. The dog was unresponsive to treatment and died. At necropsy, there was severe serofibrinous peritonitis and pleuritis, with randomly scattered dark brown necrotic foci present in multiple organs, including liver, spleen, kidney, and pancreatic lymph node. Histologically, there were extensive regions of parenchymal necrosis surrounded by neutrophils admixed with epithelioid macrophages, lymphocytes, and pigmented fungal organisms. Numerous brown, 2 to 6 microm in diameter, septate, branching hyphae, subsequently identified as Ochroconis gallopavum (formerly Dactylaria constricta var. gallopava), were observed.
一只5岁的设得兰牧羊犬出现虚弱、共济失调、贫血、血小板减少和偶尔癫痫发作的病史。这只狗因炎症性肠病接受泼尼松治疗6个月。转诊前6个月检测到犬埃立克体滴度呈阳性。初次体格检查发现一只虚弱、侧卧的狗，黏膜苍白。神经学检查发现多项神经功能缺损。全血细胞计数（CBC）显示正色素、正细胞、非再生性贫血；淋巴细胞减少；血小板减少；中性粒细胞和单核细胞增多。尿液分析显示蛋白尿，比重为1.045。这只狗对治疗无反应并死亡。尸检时，有严重的浆液纤维素性腹膜炎和胸膜炎，多个器官包括肝脏、脾脏、肾脏和胰腺淋巴结有散在的深褐色坏死灶。组织学上，有广泛的实质坏死区域，周围有中性粒细胞，并混有上皮样巨噬细胞、淋巴细胞和色素沉着的真菌生物体。观察到许多直径为2至6微米的棕色、有隔膜、分支的菌丝，随后鉴定为鸡赭曲霉（以前称为缢缩指状孢变种鸡赭曲霉）。
