钇-90微球放射性栓塞：基于MAA剂量测定法的治疗模拟的高临床影响 - Suppr

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超能文献

Radioembolization with (90)Y-loaded microspheres: high clinical impact of treatment simulation with MAA-based dosimetry.

作者信息

Garin Etienne

机构信息

Department of Nuclear Medicine, CS 44229, Cancer Institute Eugène Marquis, 35042, Rennes, France,

出版信息

Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1189-91. doi: 10.1007/s00259-015-3073-y.

DOI:10.1007/s00259-015-3073-y

PMID:25947576

Abstract

摘要

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Personalized dosimetry with intensification using 90Y-loaded glass microsphere radioembolization induces prolonged overall survival in hepatocellular carcinoma patients with portal vein thrombosis.

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The low hepatic toxicity per Gray of 90Y glass microspheres is linked to their transport in the arterial tree favoring a nonuniform trapping as observed in posttherapy PET imaging.

J Nucl Med. 2014 Jan;55(1):135-40. doi: 10.2967/jnumed.113.126839. Epub 2013 Dec 2.

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Predictive value of intratumoral 99mTc-macroaggregated albumin uptake in patients with colorectal liver metastases scheduled for radioembolization with 90Y-microspheres.

J Nucl Med. 2013 Apr;54(4):516-22. doi: 10.2967/jnumed.112.112508. Epub 2013 Feb 27.

Dosimetry based on 99mTc-macroaggregated albumin SPECT/CT accurately predicts tumor response and survival in hepatocellular carcinoma patients treated with 90Y-loaded glass microspheres: preliminary results.

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