Cahyanto Arief, Maruta Michito, Tsuru Kanji, Matsuya Shigeki, Ishikawa Kunio
Department of Biomaterials, Faculty of Dental Science, Kyushu University.
Dent Mater J. 2015;34(3):394-401. doi: 10.4012/dmj.2014-328. Epub 2015 May 1.
The objective of this study was to fabricate a type of bone cement that could fully transform to carbonate apatite (CO3Ap) in physiological conditions. A combination of calcium carbonate (CaCO3) and dicalcium phosphate anhydrous was chosen as the powder phase and mixed with one of three kinds of sodium phosphate solutions: NaH2PO4, Na2HPO4, or Na3PO4. The cement that fully transformed to CO3Ap was fabricated using vaterite, instead of calcite, as a CaCO3 source. Their stability in aqueous solutions was different, regardless of the type of sodium phosphate solution. Rate of transformation to CO3Ap in descending order was Na3PO4>Na2HPO4>NaH2PO4. Transformation rate could be affected by the pH of solution. Results of this study showed that it was advantageous to use vaterite to fabricate CO3Ap-forming cement.
本研究的目的是制备一种在生理条件下能够完全转化为碳酸磷灰石（CO3Ap）的骨水泥。选择碳酸钙（CaCO3）和无水磷酸二钙的混合物作为粉末相，并与三种磷酸钠溶液之一混合：NaH2PO4、Na2HPO4或Na3PO4。使用球霰石而非方解石作为CaCO3源制备出了完全转化为CO3Ap的骨水泥。无论磷酸钠溶液的类型如何，它们在水溶液中的稳定性都不同。转化为CO3Ap的速率由高到低依次为Na3PO4>Na2HPO4>NaH2PO4。转化率可能受溶液pH值的影响。本研究结果表明，使用球霰石制备形成CO3Ap的骨水泥具有优势。
