Synthesis and antitumour effect of N alpha-acyl derivatives of L-cystine-bis [N,N-di(2-chloroethyl)]dihydrazide.
作者信息
Zakhariev S, Stoev S, Maneva K, Ilarionova M, Todorov D, Golovinsky E
机构信息
Institute of Molecular Biology, Bulgarian Academy of Sciences, Medical Academy Sofia.
出版信息
Pharmazie. 1989 Nov;44(11):763-5.
PMID:2616623
Abstract
A series of Na-acyl derivatives of L-cystine-bis [N,N-di(2-chloroethyl)]dihydrazide was synthesized. The effect of the acyl substituent on the antitumour activity of the synthesized compounds was studied. It was demonstrated that the introduction of short-chain Na-acyl substituents resulted in substances with higher antitumour effect and lower toxicity.
摘要
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