Cardiovascular and Metabolic Diseases Etiology Research Center.
National Academy of Agricultural Science, Rural Development Administration, Jeonju, Korea and.
Int J Epidemiol. 2017 Apr 1;46(2):393-402. doi: 10.1093/ije/dyv064.
Major aetiologies of atherosclerotic cardiovascular diseases begin in childhood and atherosclerotic vascular abnormalities can be observed among children and adolescents. Adolescent cohort studies have important advantages because they can observe earlier changes in vascular structure and function. The purpose of the JS High School study (JSHS) is to identify biomarkers predicting or indicating early structural and functional vascular change in adolescents. The JSHS is a prospective cohort study of a Korean adolescent population. The target population of the JSHS was first-graders (aged 14 to17 years) at a high school of South Korea. Enrolment and baseline examinations were conducted in years 2007, 2010, 2011 and 2012. Among the total eligible population of 1115 students, 1071 (96.1%) participated in the study and completed all baseline examinations. Informed consent forms were obtained from each participant and his/her parent or guardian. Baseline examinations include: questionnaires on demographics, health behaviours, medical history, and depression symptoms; fasting blood analysis; anthropometric measurement; body impedance analysis; blood pressure measurement; radial artery tonometry; bone densitometry; pulmonary function tests; and carotid ultrasonography. Participants enrolled from 2007 through 2012 were re-examined after 30 months of follow-up, and those who enrolled in 2012 were re-examined after 24 months of follow-up. The corresponding author may be contacted for potential collaboration and data access.
动脉粥样硬化性心血管疾病的主要病因始于儿童期，儿童和青少年中可观察到动脉粥样硬化血管异常。青少年队列研究具有重要优势，因为它们可以观察到血管结构和功能的早期变化。JS 高中研究（JSHS）的目的是确定预测或提示青少年血管结构和功能早期变化的生物标志物。JSHS 是一项针对韩国青少年人群的前瞻性队列研究。JSHS 的目标人群是韩国一所高中的一年级学生（年龄 14 至 17 岁）。招募和基线检查分别于 2007 年、2010 年、2011 年和 2012 年进行。在总共 1115 名符合条件的学生中，有 1071 名（96.1%）参加了研究并完成了所有基线检查。每位参与者及其父母或监护人都获得了知情同意书。基线检查包括：人口统计学、健康行为、病史和抑郁症状的问卷；空腹血液分析；人体测量；身体阻抗分析；血压测量；桡动脉张力计；骨密度测定；肺功能检查；颈动脉超声检查。2007 年至 2012 年期间招募的参与者在随访 30 个月后再次接受检查，2012 年招募的参与者在随访 24 个月后再次接受检查。潜在合作和数据访问请联系通讯作者。
