Goodwin G M, Shapiro C M, Bennie J, Dick H, Carroll S, Fink G
MRC Brain Metabolism Unit, University Department of Psychiatry, Royal Edinburgh Hospital.
Psychol Med. 1989 Nov;19(4):857-64. doi: 10.1017/s0033291700005572.
The secretion of prolactin and growth hormone (GH), together with subjective ratings of sedation and hunger, were determined in 13 in-patients with anorexia nervosa and 15 controls during the intravenous infusion of L-tryptophan (100 mg/kg). Prolactin responses were not different between groups but GH responses were markedly blunted in patients. In addition sedation responses in patients were attenuated compared with controls. Hunger ratings were reduced by the infusion in controls but were too variable to be interpreted in the patients. Plasma amino acid levels were also determined before and after infusion of L-tryptophan. Tryptophan levels were comparable in the two groups as were the levels of tyrosine, phenyl alanine, valine, leucine and iso-leucine. The results suggest that some aspects of 5-hydroxytryptamine function may be attenuated in anorexia nervosa. However, they undoubtedly contrast with the finding of enhanced hormonal responses in acute dieting and may be relevant to the interpretation of similar experiments in depressive illness.
在13名神经性厌食症住院患者和15名对照组中，于静脉输注L - 色氨酸（100mg/kg）期间，测定了催乳素和生长激素（GH）的分泌，以及镇静和饥饿的主观评分。两组间催乳素反应无差异，但患者的GH反应明显减弱。此外，与对照组相比，患者的镇静反应减弱。对照组中输注可降低饥饿评分，但患者的饥饿评分变化太大，无法进行解读。还测定了输注L - 色氨酸前后的血浆氨基酸水平。两组的色氨酸水平以及酪氨酸、苯丙氨酸、缬氨酸、亮氨酸和异亮氨酸水平相当。结果表明，5 - 羟色胺功能的某些方面在神经性厌食症中可能减弱。然而，它们无疑与急性节食时激素反应增强的发现形成对比，并且可能与抑郁症类似实验的解释有关。
