Goodwin G M, Fairburn C G, Cowen P J
University Department of Psychiatry, Oxford, England.
Arch Gen Psychiatry. 1987 Nov;44(11):952-7. doi: 10.1001/archpsyc.1987.01800230032007.
The increases in the growth hormone (GH) level following intravenous infusion of the 5-hydroxytryptamine precursor tryptophan, the alpha 2-adrenoceptor agonist clonidine hydrochloride, and subcutaneous injection of the dopamine agonist apomorphine hydrochloride were determined in volunteers before and in the third week of a weight-reducing diet (1200 kcal/d). The increases in the prolactin level following intravenous infusion of tryptophan and in response to protirelin were also determined. In male subjects, the GH responses to tryptophan and apomorphine were markedly increased by dieting; while also significantly increased, the GH responses to clonidine were much less affected. Female subjects showed similar trends in the GH responses to tryptophan and clonidine. In male subjects, prolactin responses to tryptophan and protirelin were not increased by dieting. In females, the prolactin response to protirelin was similarly not increased, but the prolactin response to tryptophan was markedly enhanced. These results are relevant to the use of neuroendocrine tests in depression. In addition, they suggest different effects of weight loss on neurotransmitter function in men and women.
在志愿者进行减重饮食（1200千卡/天）前及第三周时，测定静脉输注5-羟色胺前体色氨酸、α2-肾上腺素能受体激动剂盐酸可乐定以及皮下注射多巴胺激动剂盐酸阿扑吗啡后生长激素（GH）水平的升高情况。还测定了静脉输注色氨酸后及对促甲状腺激素释放激素反应时催乳素水平的升高情况。在男性受试者中，节食使GH对色氨酸和阿扑吗啡的反应显著增强；GH对可乐定的反应虽也显著增加，但受影响程度小得多。女性受试者对色氨酸和可乐定的GH反应呈现相似趋势。在男性受试者中，节食未增加催乳素对色氨酸和促甲状腺激素释放激素的反应。在女性中，催乳素对促甲状腺激素释放激素的反应同样未增加，但催乳素对色氨酸的反应显著增强。这些结果与神经内分泌测试在抑郁症中的应用相关。此外，它们提示体重减轻对男性和女性神经递质功能有不同影响。
