一项关于合成树脂制造行业中职业性接触溶剂的工人神经行为表现的研究。
A study on neurobehavioral performance of workers occupationally exposed to solvent in synthetic resin manufacturing.
作者信息
Saha Asim, Tripathi S R
机构信息
Department of Epidemiology, Regional Occupational Health Centre (Eastern), Salt Lake, Kolkata, West Bengal, India.
Department of Psychology, National Institute of Occupational Health, Ahmedabad, Gujarat, India.
出版信息
Toxicol Int. 2014 Sep-Dec;21(3):264-8. doi: 10.4103/0971-6580.155346.
BACKGROUND
One major effect of occupational solvent exposure is central nervous system (CNS) impairment, ranging from depression to encephalopathy with cognitive, behavioral changes. Exposures in industries being varied, classification of health outcomes for different exposures is important.
OBJECTIVES
This study assessed neurobehavioral performance of synthetic resin manufacturing workers exposed to organic solvent, mainly formalin.
MATERIALS AND METHODS
This cross-sectional study selected subjects by random selection from all such workers of an Indian city. Questionnaire survey and assessment by a neurobehavioral test battery (NBT) was undertaken.
RESULTS
Comparison between actual and allied workers observed significant difference in tweezer dexterity, card sorting and backward memory scores. Significant effect of exposure was observed on tweezer dexterity, card sorting, and hand dynamometer scores.
CONCLUSION
Changes of neurobehavioral performance might occur following solvent exposure and these changes might have a relationship with the quantum of exposure. Periodic examination of workers with NBT is needed for detection of early neurotoxic effects.
背景
职业性接触溶剂的一个主要影响是中枢神经系统（CNS）损害，范围从抑郁到伴有认知、行为改变的脑病。行业中的接触情况各不相同，对不同接触情况的健康结果进行分类很重要。
目的
本研究评估了接触有机溶剂（主要是福尔马林）的合成树脂制造工人的神经行为表现。
材料与方法
这项横断面研究从印度一个城市的所有此类工人中随机选择受试者。进行了问卷调查和神经行为测试组合（NBT）评估。
结果
实际工人与相关工人之间的比较显示，镊子灵巧度、卡片分类和逆向记忆得分存在显著差异。观察到接触对镊子灵巧度、卡片分类和握力计得分有显著影响。
结论
接触溶剂后可能会发生神经行为表现的变化，这些变化可能与接触量有关。需要定期用NBT对工人进行检查以检测早期神经毒性作用。
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