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乙醇对基底外侧杏仁核神经回路活动的调节作用

Modulation of neural circuit actvity by ethanol in basolateral amygdala.

作者信息

Chung Leeyup

机构信息

Dept. of Pediatrics, Duke University School of Medicine, Durham, NC27710, USA.

出版信息

Dev Reprod. 2012 Dec;16(4):265-70. doi: 10.12717/DR.2012.16.4.265.

DOI:10.12717/DR.2012.16.4.265
PMID:25949099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4282243/
Abstract

Ethanol actions in the amygdala formation may underlie in part the reinforcing effects of ethanol consumption. Previously a physiological phenomenon in the basolateral amygdala (BLA) that is dependent on neuronal network activity, compound postsynaptic potentials (cPSPs) were characterized. Effects of acute ethanol application on the frequency of cPSPs were subsequently investigated. Whole cell patch clamp recordings were performed from identified projection neurons in a rat brain slice preparation containing the amygdala formation. Acute ethanol exposure had complex effects on cPSP frequency, with both increases and decreases dependent on concentration, duration of exposure and age of the animal. Ethanol produces complex biphasic effects on synaptically-driven network activity in the BLA. These findings may relate to subjective effects of ethanol on arousal and anxiolysis in humans.

摘要

杏仁核结构中的乙醇作用可能部分是乙醇摄入强化效应的基础。以前，基底外侧杏仁核（BLA）中一种依赖神经元网络活动的生理现象——复合突触后电位（cPSPs）已得到表征。随后研究了急性应用乙醇对cPSPs频率的影响。在包含杏仁核结构的大鼠脑片标本中，从已鉴定的投射神经元进行全细胞膜片钳记录。急性乙醇暴露对cPSP频率有复杂影响，增加和减少都取决于浓度、暴露持续时间和动物年龄。乙醇对BLA中突触驱动的网络活动产生复杂的双相效应。这些发现可能与乙醇对人类觉醒和抗焦虑的主观效应有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c3/4282243/ab22f2d90a61/devrepro-16-265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c3/4282243/32b0e41d5b6a/devrepro-16-265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c3/4282243/ab22f2d90a61/devrepro-16-265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c3/4282243/32b0e41d5b6a/devrepro-16-265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c3/4282243/ab22f2d90a61/devrepro-16-265-g002.jpg

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本文引用的文献

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Neuroscience. 2009 Dec 29;164(4):1389-97. doi: 10.1016/j.neuroscience.2009.09.061. Epub 2009 Sep 25.
2
Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine.乙醇和可卡因诱发的运动在基因上与伏隔核多巴胺的增加有关。
Genes Brain Behav. 2009 Apr;8(3):346-55. doi: 10.1111/j.1601-183X.2009.00481.x. Epub 2009 Feb 11.
3
Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function.
经选择性培育以产生高或低酒精诱导运动能力的小鼠，在多巴胺神经元功能上存在差异。
J Pharmacol Exp Ther. 2009 Apr;329(1):342-9. doi: 10.1124/jpet.108.146316. Epub 2009 Jan 2.
4
Ethanol/naltrexone interactions at the mu-opioid receptor. CLSM/FCS study in live cells.乙醇/纳曲酮在μ-阿片受体上的相互作用。活细胞中的共聚焦激光扫描显微镜/荧光相关光谱研究。
PLoS One. 2008;3(12):e4008. doi: 10.1371/journal.pone.0004008. Epub 2008 Dec 23.
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The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol.新型微阿片受体拮抗剂[N-烯丙基-Dmt(1)]内吗啡肽-2可减弱乙醇对γ-氨基丁酸能神经传递的增强作用。
Alcohol Alcohol. 2009 Jan-Feb;44(1):13-9. doi: 10.1093/alcalc/agn085. Epub 2008 Oct 29.
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Alcohol inhibits spontaneous activity of basolateral amygdala projection neurons in the rat: involvement of the endocannabinoid system.酒精抑制大鼠基底外侧杏仁核投射神经元的自发活动：内源性大麻素系统的作用
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