Bryant Kathleen G, Swygart David, Yin Yuexi, Bauer Meredith R, Morningstar Mitchell D, Timme Nicholas M, Barnett William H, McGonigle Colleen E, Engleman Eric A, Sheets Patrick L, Lapish Christopher C
Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, USA.
iScience. 2025 Jun 17;28(7):112920. doi: 10.1016/j.isci.2025.112920. eCollection 2025 Jul 18.
Acute alcohol can have profound effects on the brain and behavior. Dorsal medial prefrontal cortex (dmPFC) function is especially sensitive to disruption from acute alcohol exposure. The acute, broadly inhibitory pharmacodynamics of alcohol in dmPFC have been well characterized in and preparations, but seemingly contradict the stimulatory behavioral effects of alcohol at low-to-moderate doses. To determine the effects of acute alcohol on dmPFC activity, this study combined multiple routes of alcohol exposure across multiple rodent species and preparations and utilized modeling techniques to make direct predictions about brain ethanol concentrations. These findings revealed that the acute effects of alcohol on dmPFC are actually biphasic in nature, such that broad reductions in activity are immediately followed by broad increases in neural activity. Notably, these increases in neural activity were only observed in preparations, suggesting that network engagement and exposure route may be critical.
急性酒精会对大脑和行为产生深远影响。背内侧前额叶皮质（dmPFC）功能对急性酒精暴露造成的干扰尤为敏感。酒精在dmPFC中的急性、广泛抑制性药效学已在[具体文献1]和[具体文献2]的实验准备中得到充分表征，但这似乎与低至中等剂量酒精的刺激性行为效应相矛盾。为了确定急性酒精对dmPFC活动的影响，本研究结合了多种啮齿动物物种和实验准备中的多种酒精暴露途径，并利用建模技术对脑乙醇浓度进行直接预测。这些发现表明，酒精对dmPFC的急性影响实际上具有双相性，即活动的广泛降低之后紧接着是神经活动的广泛增加。值得注意的是，这些神经活动的增加仅在[具体实验准备]中观察到，这表明网络参与和暴露途径可能至关重要。
