Bouchard Josée, Madore François
Division of Nephrology, Department of Medicine, Hôpital du Sacré-Coeur de Montréal , Université de Montréal , Montreal, Quebec , Canada.
NDT Plus. 2009 Feb;2(1):11-9. doi: 10.1093/ndtplus/sfn184. Epub 2008 Dec 9.
Anticoagulation is required during continuous renal replacement therapy to prevent filter clotting and optimize filter performance. However, anticoagulation may also be associated with serious bleeding complications. Patients with liver failure often suffer from underlying coagulopathy and are especially prone to anticoagulation complications. The aim of this review is to present the unique features of patients with hepatic injury in terms of anticoagulation disorders and to analyze data on safety and efficacy of the different anticoagulation methods for liver failure patients undergoing continuous renal replacement therapy.
在持续肾脏替代治疗期间需要进行抗凝，以防止滤器凝血并优化滤器性能。然而，抗凝也可能与严重的出血并发症相关。肝功能衰竭患者常伴有潜在的凝血功能障碍，尤其容易出现抗凝并发症。本综述的目的是阐述肝损伤患者在抗凝紊乱方面的独特特征，并分析不同抗凝方法用于接受持续肾脏替代治疗的肝功能衰竭患者的安全性和有效性数据。
