Dalton Kristen, Smith Maxwell, Thurman Joshua M
Department of Medicine, School of Medicine , University of Colorado Denver , Denver, CO , USA.
Departments of Pathology and Medicine, School of Medicine , University of Colorado Denver , Aurora, CO , USA.
NDT Plus. 2010 Aug;3(4):346-8. doi: 10.1093/ndtplus/sfq046. Epub 2010 Apr 13.
The transformation of lupus nephritis from one histologic pattern to another is well described. We report a case of a patient who initially presented with diffuse proliferative glomerulonephritis and was treated with prednisone and mycophenolate mofetil (MMF). She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. A repeat biopsy performed after the increase in proteinuria demonstrated that she had focal proliferative disease but that she had also developed membranous lupus nephritis. Our case is unique in that we report a patient who developed membranous lupus nephritis while receiving MMF.
狼疮性肾炎从一种组织学类型转变为另一种类型已有充分描述。我们报告一例患者，该患者最初表现为弥漫性增殖性肾小球肾炎，接受泼尼松和霉酚酸酯（MMF）治疗。她最初对治疗反应良好，但后来在仍使用MMF和小剂量类固醇时出现了大量蛋白尿。蛋白尿增加后进行的重复活检显示，她患有局灶性增殖性疾病，同时也发展为膜性狼疮性肾炎。我们的病例独特之处在于，我们报告了一名在接受MMF治疗时发生膜性狼疮性肾炎的患者。
