Lee H S, Mujais S K, Kasinath B S, Spargo B H, Katz A I
Am J Med. 1984 Oct;77(4):612-20. doi: 10.1016/0002-9343(84)90350-4.
Evaluation of the course of lupus nephropathy by serial kidney biopsy in 50 patients revealed a complex pattern of transitions from one histologic class to another. A high rate of transformations (56 percent) was observed, with fewer than half the patients remaining in the original category. Although the general trend was towards transformation to a less severe lesion (WHO classes III and IV transforming into classes II and V), this was certainly not the rule for all individual classes. These transformations were rarely predictable on the basis of available clinical, laboratory, or pathologic information, and were less common in younger patients. These results help clarify the pathologic behavior of lupus nephropathy in the modern therapeutic era and highlight the value of pathologic examination for the planning and evaluation of therapy in selected patients.
对50例患者进行系列肾活检以评估狼疮性肾炎的病程，结果显示从一种组织学类型转变为另一种类型的模式复杂。观察到较高的转变率（56%），只有不到一半的患者仍处于原来的类别。尽管总体趋势是转变为较轻的病变（世界卫生组织III级和IV级转变为II级和V级），但这肯定不是所有个体类别的规律。根据现有的临床、实验室或病理信息，这些转变很少能被预测，且在年轻患者中不太常见。这些结果有助于阐明现代治疗时代狼疮性肾炎的病理行为，并突出病理检查在选定患者治疗规划和评估中的价值。
