Speeckaert Marijn M, Segers Hannah, Van Biesen Wim, Verstraete Alain, Langlois Michel R, Delanghe Joris R
Department of Clinical Chemistry , Ghent University Hospital , Gent , Belgium.
Department of Nephrology , Ghent University Hospital , Gent , Belgium.
NDT Plus. 2010 Dec;3(6):570-2. doi: 10.1093/ndtplus/sfq148. Epub 2010 Aug 5.
A high concentration of glycerol in plasma is an interfering factor in the determination of triglycerides, giving rise to (pseudo)hypertriglyceridaemia. Hyperglycerolaemia may be due to the presence of exogenous glycerol or due to endogenous glycerol accumulation. In the present case report, a 57-year-old male patient with end-stage renal disease presented with a pseudohypertriglyceridaemia based on a pronounced hyperglycerolaemia. The hyperglycerolaemia was due to chronic intake of glycerol-containing alcoholic beverages in combination with a reduced glycerol clearance and glycerol kinase activity. In conclusion, an unexplained hypertriglyceridaemia in patients with an impaired renal function should raise the suspicion of hyperglycerolaemia.
血浆中高浓度甘油是甘油三酯测定的干扰因素,可导致(假性)高甘油三酯血症。高甘油血症可能是由于外源性甘油的存在,也可能是由于内源性甘油蓄积。在本病例报告中,一名57岁终末期肾病男性患者因明显的高甘油血症出现假性高甘油三酯血症。高甘油血症是由于长期摄入含甘油的酒精饮料,同时甘油清除率和甘油激酶活性降低所致。总之,肾功能受损患者出现无法解释的高甘油三酯血症应怀疑高甘油血症。