Suzuki M, Watanabe M, Suzuki K, Nakano K, Kaneko I
Division of Radiation Biology, School of Medicine, Yokohama City University, Japan.
Radiat Res. 1989 Dec;120(3):468-76.
We have studied the induction of morphological transformation by heavy ions. Golden hamster embryo cells were irradiated with 95 MeV 14N ions (530 keV/microns), 22 MeV 4He ions (36 keV/microns), and 22 MeV 4He ions with a 100-microns Al absorber (77 keV/microns) which were generated by a cyclotron at the Institute of Physical and Chemical Research in Japan. Colonies were considered to contain neoplastically transformed cells when the cells were densely stacked and made a crisscross pattern. It was shown that the induction of transformation was much more effective with 14N and 4He ions than with gamma or X rays. The relative biological effectiveness (RBE) relative to 60Co gamma rays was 3.3 for 14N ions, 2.4 for 4He ions, and 3.3 for 4He ions with a 100-microns Al absorber. The relationship between RBE and linear energy transfer was qualitatively similar for both cell death and transformation.
我们研究了重离子诱导的形态转化。用日本理化研究所回旋加速器产生的95兆电子伏特的氮离子（530千电子伏特/微米）、22兆电子伏特的氦离子（36千电子伏特/微米）以及带有100微米铝吸收体的22兆电子伏特氦离子（77千电子伏特/微米）辐照金黄地鼠胚胎细胞。当细胞密集堆积并形成交叉图案时，这些菌落被认为含有肿瘤转化细胞。结果表明，与γ射线或X射线相比，氮离子和氦离子诱导转化的效果要显著得多。相对于60钴γ射线，氮离子的相对生物效应（RBE）为3.3，氦离子为2.4，带有100微米铝吸收体的氦离子为3.3。细胞死亡和转化的RBE与传能线密度之间的关系在定性上是相似的。
