Govorun R D, Nasonova E A, Krasavin E A, Kozubek S, Cherevatenko A P
Radiobiologiia. 1987 Mar-Apr;27(2):177-81.
Radiosensitivity of Chinese hamster cells exposed to 137Cs-gamma-radiation and accelerated heavy ions of 4He (L = 22 and 60 keV/micron), 12C (L = 231 keV/micron), and 20Ne (L = 690 keV/micron) was studied in standard conditions and in the presence of arabinosylcytosine and hydroxyurea. These agents were shown to exert a radiosensitizing effect in the case of gamma-radiation. The effect was less pronounced with 4He ion-radiation and was absent upon irradiation with 12C and 20Ne ions. The radiosensitivity was maximum upon irradiation with 4He ions at L = 60 keV/micron. The RBE coefficients of heavy ions under study decreased in the presence of DNA synthesis inhibitors.
研究了中国仓鼠细胞在标准条件下以及在存在阿糖胞苷和羟基脲的情况下，暴露于137Cs-γ射线以及4He（线能量传递L = 22和60 keV/μm）、12C（L = 231 keV/μm）和20Ne（L = 690 keV/μm）的加速重离子时的放射敏感性。结果表明，这些试剂在γ射线照射时具有放射增敏作用。对于4He离子辐射，这种作用不太明显，而在用12C和20Ne离子照射时则不存在。在用L = 60 keV/μm的4He离子照射时，放射敏感性最高。在所研究的重离子存在DNA合成抑制剂的情况下，其相对生物学效应（RBE）系数降低。
