Fox S W, Syren R M, Windsor C R
Ciba Found Symp. 1978(67):175-93. doi: 10.1002/9780470720493.ch12.
A number of copoly(alpha-amino acids) have been prepared thermally; some have been found to function as inhibitors of glyoxalase I, an enzyme which occupies a central position in Szent-Györgyi's theory of tumour genesis. These polymers are also of interest in the search for synthetic peptides having carcinostatic activity, since many natural peptides are active. The way in which the inhibitory activity varies with composition of the synthetic polymers has been investigated. Various properties (hydrophobicity, molecular weight, u.v. absorption, kinetic type) have been examined in a search for correlates of inhibitory activity. The relationship to the origin of enzyme control mechanisms is discussed.
已经通过热法制备了多种共聚（α-氨基酸）；其中一些被发现可作为乙二醛酶I的抑制剂，该酶在圣捷尔吉的肿瘤发生理论中占据核心地位。这些聚合物在寻找具有抗癌活性的合成肽方面也很有意义，因为许多天然肽都具有活性。已经研究了抑制活性随合成聚合物组成变化的方式。为了寻找抑制活性的相关因素，已经研究了各种性质（疏水性、分子量、紫外吸收、动力学类型）。讨论了与酶控制机制起源的关系。
