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Inhibition of glyoxalase I by various clinically used anticancer drugs.

作者信息

Kraus J L, Pernice P, Ponce C

机构信息

Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 Mar;59(3):419-22.

PMID:3363227
Abstract

The antiglyoxalase activity of eight well-known anticancer drugs has been evaluated, their I50 values were determinated and compared to those of standard inhibitors S-octylglutathione and squaric acid. Among them methotrexate was found to be as potent as S-octylglutathione.

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