多种临床使用的抗癌药物对乙二醛酶I的抑制作用。
Inhibition of glyoxalase I by various clinically used anticancer drugs.
作者信息
Kraus J L, Pernice P, Ponce C
机构信息
Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.
出版信息
Res Commun Chem Pathol Pharmacol. 1988 Mar;59(3):419-22.
PMID:3363227
Abstract
The antiglyoxalase activity of eight well-known anticancer drugs has been evaluated, their I50 values were determinated and compared to those of standard inhibitors S-octylglutathione and squaric acid. Among them methotrexate was found to be as potent as S-octylglutathione.
摘要
评估了八种知名抗癌药物的抗乙二醛酶活性，测定了它们的半数抑制浓度（IC50）值，并与标准抑制剂S-辛基谷胱甘肽和方酸的IC50值进行比较。其中发现甲氨蝶呤与S-辛基谷胱甘肽的效力相当。
Zotero 插件