Ekins Sean, Southan Christopher, Coffee Megan
Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina, NC, 27526, USA ; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, USA.
IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, UK.
F1000Res. 2015 Feb 27;4:58. doi: 10.12688/f1000research.6181.2. eCollection 2015.
The current Ebola virus epidemic may provide some suggestions of how we can better prepare for the next pathogen outbreak. We propose several cost effective steps that could be taken that would impact the discovery and use of small molecule therapeutics including: 1. text mine the literature, 2. patent assignees and/or inventors should openly declare their relevant filings, 3. reagents and assays could be commoditized, 4. using manual curation to enhance database links, 5. engage database and curation teams, 6. consider open science approaches, 7. adapt the "box" model for shareable reference compounds, and 8. involve the physician's perspective.
当前的埃博拉病毒疫情或许能为我们如何更好地应对下一次病原体爆发提供一些建议。我们提出了几个具有成本效益的步骤，这些步骤可能会影响小分子疗法的发现和使用，包括：1. 对文献进行文本挖掘；2. 专利受让人和/或发明人应公开披露其相关申请；3. 试剂和检测方法可以商品化；4. 利用人工整理来加强数据库链接；5. 让数据库和整理团队参与进来；6. 考虑开放科学方法；7. 采用“盒子”模型来共享参考化合物；8. 纳入医生的观点。
