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吲哚胺2,3-双加氧酶疫苗接种。

Indoleamine 2,3-dioxygenase vaccination.

作者信息

Andersen Mads Hald, Svane Inge Marie

机构信息

Department of Hematology; Center for Cancer Immune Therapy (CCIT); Copenhagen University Hospital ; Herlev, Denmark.

Department of Hematology; Center for Cancer Immune Therapy (CCIT); Copenhagen University Hospital ; Herlev, Denmark ; Department of Oncology; Copenhagen University Hospital ; Herlev, Denmark.

出版信息

Oncoimmunology. 2015 Feb 3;4(1):e983770. doi: 10.4161/2162402X.2014.983770. eCollection 2015 Jan.

DOI:10.4161/2162402X.2014.983770
PMID:25949864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4368142/
Abstract

Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were vaccinated with an IDO-derived HLA-A2-restricted epitope.

摘要

吲哚胺2,3-双加氧酶（IDO）是一种免疫调节酶。值得注意的是，我们发现了IDO特异性T细胞，其可影响癌症患者的适应性免疫反应。此外，最近的一项I期临床试验表明，用IDO衍生的HLA - A2限制性表位进行疫苗接种的非小细胞肺癌（NSCLC）患者可实现持久的疾病稳定且无毒性。

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本文引用的文献

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FOXP3-specific immunity.FOXP3特异性免疫
Oncoimmunology. 2013 Oct 1;2(10):e26247. doi: 10.4161/onci.26247. Epub 2013 Sep 12.
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Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.转移性肺癌患者接种吲哚胺 2,3 双加氧酶表位疫苗后无毒性的疾病长期稳定。
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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.基于吲哚胺2,3-双加氧酶降解色氨酸的肿瘤免疫抵抗机制的证据。
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