Lorenc J, Kozak-Michałowska I, Polkowska-Kulesza E
Przegl Lek. 1989;46(10):713-8.
The study comprised 128 patients with chronic lymphocytic leukemia (CLL) aged 65.7 +/- 8 years, 59 women and 69 men. Among the patients studied 70 were treated and 58 yet not underwent therapy. The Rai classification of patients with CLL has been used. The control group consisted of 68 subjects aged 56.8 +/- 14 years, 35 women and 33 men, showing no diseases affecting the blood lipid disturbances. The following determinations have been performed in the blood serum: apo B, CH, TG, PL, and CH or PL in the isolated HDL fraction; LDL-CH ratio has also been calculated. In patients with CLL the total CH concentration has been noted which advanced parallel to the disease progress. It resulted first of all from the decrease in LDL-CH (p less than 0.05). Similar alterations have been noted so far as apo B is concerned. It has been demonstrated that the decrease in HDL-CH (p less than 0.05) is also dependent on the disease stage. The simultaneously increasing index HDL-PL/HDL-CH indicate on changes within the HDL2 and HDL3 subfractions suggesting a deficiency of the HDL2 subfraction. The total lipemia and the lipoprotein fraction alterations observed make the diagnostic value of the atherosclerotic threat in patients with CLL doubtful with the use of that parameters.
该研究纳入了128例慢性淋巴细胞白血病（CLL）患者，年龄为65.7±8岁，其中59例女性，69例男性。在研究的患者中，70例接受了治疗，58例尚未接受治疗。采用了CLL患者的Rai分期。对照组由68名受试者组成，年龄为56.8±14岁，其中35例女性，33例男性，未发现有影响血脂紊乱的疾病。对血清进行了以下测定：载脂蛋白B、总胆固醇（CH）、甘油三酯（TG）、磷脂（PL），以及分离的高密度脂蛋白（HDL）组分中的CH或PL；还计算了低密度脂蛋白胆固醇（LDL-CH）比值。在CLL患者中，观察到总CH浓度随着疾病进展而升高。这首先是由于LDL-CH降低（p<0.05）所致。就载脂蛋白B而言，也观察到了类似变化。已证明HDL-CH降低（p<0.05）也取决于疾病阶段。同时升高的HDL-PL/HDL-CH指数表明HDL2和HDL3亚组分发生了变化，提示HDL2亚组分缺乏。观察到的总脂血症和脂蛋白组分改变使得使用这些参数来判断CLL患者动脉粥样硬化风险的诊断价值存疑。
