Qin Hong, Wei Guowei, Gwak Dongho, Dong Zhenyuan, Xiong Ailian, Kwak Larry W
Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
Oncoimmunology. 2015 Apr 2;4(3):e983961. doi: 10.4161/2162402X.2014.983761. eCollection 2015 Mar.
Tumor-associated myeloid cells undermine the therapeutic efficacy of cancer immunotherapy by their inhibitory properties on immune effector cells. Development of therapeutic agents to deplete suppressive myeloid cells in tumor microenvironment requires identification of cell-specific targets. A competitive phage display technique on live cells paves the way to discovery of such a target.
肿瘤相关髓样细胞通过其对免疫效应细胞的抑制特性破坏癌症免疫治疗的疗效。开发用于清除肿瘤微环境中抑制性髓样细胞的治疗药物需要鉴定细胞特异性靶点。活细胞上的竞争性噬菌体展示技术为发现此类靶点铺平了道路。