Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering, Collaborative Innovation Center for Coal Based Energy (i-CCE), East China University of Science & Technology, Shanghai 200237 (China).
PerkinElmer Instruments (Shanghai) Co. Zhangheng Road 1670 Shanghai 201203 (China).
Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7275-80. doi: 10.1002/anie.201501478. Epub 2015 May 7.
The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.
用于体内癌症靶向的高性能荧光材料的合理设计仍然具有挑战性。本文提出了一种独特的分子设计策略，涉及对聚集诱导发射（AIE）活性有机分子进行剪裁，以实现更好的远红和近红外荧光、良好控制的形态（从棒状到球状），以及肿瘤靶向生物成像。经形状剪裁的有机喹啉-丙二腈（QM）纳米探针具有生物相容性，非常适合用于细胞跟踪应用。令人印象深刻的是，QM-5 纳米聚集体的球形在静脉注射到小鼠后表现出优异的肿瘤靶向生物成像性能，而 QM-2 的棒状聚集体则没有。
