聚集诱导发光（AIE），生命与健康。
Aggregation-Induced Emission (AIE), Life and Health.
机构信息
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, China.
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.
出版信息
ACS Nano. 2023 Aug 8;17(15):14347-14405. doi: 10.1021/acsnano.3c03925. Epub 2023 Jul 24.
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.
光对现代医学和医疗保健产生了深远的影响，目前有许多发光试剂和成像技术被用于评估健康状况和治疗疾病。作为一种新兴的发光概念，聚集诱导发光（AIE）因其在亮度、生物相容性、光稳定性以及与浓度的正相关性方面的优势，在生物应用中显示出巨大的潜力。本综述全面总结了应用于生物结构和动态生理过程成像、疾病诊断和治疗以及特定分析物的检测和监测的 AIE 发光体的研究进展，并介绍了代表性工作。文中还讨论了关键问题和对未来发展方向的展望。希望本综述能够激发来自化学、生物学、材料科学、医学等不同领域研究人员的兴趣，从而促进 AIE 在生命和健康领域的发展。
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