新生儿黄疸与儿童过敏性疾病风险：一项基于人群的队列研究。
Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study.
作者信息
Wei Chang-Ching, Lin Cheng-Li, Shen Te-Chun, Kao Chia-Hung
机构信息
1] Children's Hospital, China Medical University Hospital, Taichung, Taiwan [2] College of Medicine, China Medical University, Taichung, Taiwan.
1] College of Medicine, China Medical University, Taichung, Taiwan [2] Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
出版信息
Pediatr Res. 2015 Aug;78(2):223-30. doi: 10.1038/pr.2015.89. Epub 2015 May 7.
BACKGROUND
Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases.
METHODS
From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated.
RESULTS
The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion.
CONCLUSION
Neonatal jaundice is associated with the development of allergic diseases in early childhood.
背景
仅有少数研究系统分析了新生儿黄疸与儿童期过敏性疾病之间的关联。
方法
2000年至2007年期间，共确定了27693例新诊断为新生儿黄疸的新生儿以及55367例匹配的非新生儿黄疸队列。计算了截至2008年底五种过敏性疾病（即过敏性结膜炎（AC）、过敏性鼻炎（AR）、特应性皮炎（AD）、哮喘和荨麻疹）的发病率和风险比（HRs）。
结果
新生儿黄疸队列中五种过敏性疾病的发病密度和HRs高于非新生儿黄疸队列，且HRs随年龄略有下降。AR（HR = 2.51，95%置信区间（CI）= 2.43 - 2.59）和AD（HR = 2.51，95% CI = 2.40 - 2.62）的HRs最高，荨麻疹的HRs最低（HR = 2.06，95% CI = 1.94 - 2.19）。男孩和需要光疗的患儿患过敏性疾病的HRs显著更高。无论患者是否接受换血治疗，新生儿黄疸患儿中除荨麻疹外（HR = 2.49，95% CI = 1.57 - 3.97）的过敏性疾病HRs无显著差异。
结论
新生儿黄疸与儿童早期过敏性疾病的发生有关。
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