Department of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt.
Department of Public Health, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt.
Am J Perinatol. 2020 Nov;37(13):1357-1363. doi: 10.1055/s-0039-1693697. Epub 2019 Jul 31.
The current study aims to assess the association between different characteristics of neonatal jaundice and common types of allergic diseases in childhood (as bronchial asthma, acute urticaria, and allergic rhinitis).
A case-control study is conducted on 300 allergic children and 300 healthy children as a control group at Fayoum University Hospital. The study was conducted over a span of 2 years, from May 2016 to May 2018. Bronchial asthma, allergic rhinitis, and acute urticaria diagnoses were based on physician clinical examination using specific guidelines for each. For the data regarding children's demographic and maternal characteristics, a structured questionnaire was used. Regarding neonatal jaundice, data were collected from the patients' hospital records.
Children with neonatal jaundice are more likely to develop allergy with 57% higher than neonates without jaundice. Early onset jaundice and treatment by phototherapy have statistically significant association with the development of allergic diseases.
Different aspects of neonatal jaundice are associated with the development of common allergic diseases in children.
本研究旨在评估新生儿黄疸的不同特征与儿童常见过敏性疾病（如支气管哮喘、急性荨麻疹和过敏性鼻炎）之间的关系。
在法尤姆大学医院进行了一项病例对照研究，共纳入 300 名过敏性儿童和 300 名健康儿童作为对照组。该研究于 2016 年 5 月至 2018 年 5 月进行。支气管哮喘、过敏性鼻炎和急性荨麻疹的诊断基于医生根据每个疾病的具体指南进行的临床检查。对于儿童人口统计学和母婴特征的数据，使用了结构化问卷。对于新生儿黄疸的数据，从患者的医院记录中收集。
患有新生儿黄疸的儿童更有可能发生过敏，其过敏发生率比无黄疸的新生儿高 57%。早发型黄疸和光疗治疗与过敏性疾病的发生有统计学显著关联。
新生儿黄疸的不同方面与儿童常见过敏性疾病的发生有关。
