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全球定位系统在社区中用于评估血管重建术后步行能力的改善:一项针对外周动脉疾病患者进行6个月随访的前瞻性多中心研究。

Global positioning system use in the community to evaluate improvements in walking after revascularization: a prospective multicenter study with 6-month follow-up in patients with peripheral arterial disease.

作者信息

Gernigon Marie, Le Faucheur Alexis, Fradin Dominique, Noury-Desvaux Bénédicte, Landron Cédric, Mahe Guillaume, Abraham Pierre

机构信息

From the Laboratory for Vascular Investigations. University Hospital (MG, PA); Laboratory of Physiology, CNRS, UMR6214; Inserm, U771; Medical School, University of Angers (MG, BN-D, PA); Movement, Sport and Health laboratory (M2S). EA 1274. UFR APS, University of Rennes, Rennes (ALF); Ecole normale supérieure de Rennes, Rennes (ENS Rennes); Department of Sports Science and Physical Education, Bruz (ALF); INSERM, Clinical Investigation Center (CIC 1414), Rennes (ALF, GM); Centre Hospitalier, Le Mans (DF, BN-D); IFEPSA, Apcoss (BN-D); Centre Hospitalier Universitaire, Poitiers (CL); and University Hospital of Rennes, Rennes, France (GM).

出版信息

Medicine (Baltimore). 2015 May;94(18):e838. doi: 10.1097/MD.0000000000000838.

Abstract

UNLABELLED

Revascularization aims at improving walking ability in patients with arterial claudication. The highest measured distance between 2 stops (highest-MDCW), the average walking speed (average-WSCW), and the average stop duration (average-DSCW) can be measured by global positioning system, but their evolution after revascularization is unknown.We included 251 peripheral artery diseased patients with self-reported limiting claudication. The patients performed a 1-hour stroll, recorded by a global positioning system receiver. Patients (n = 172) with confirmed limitation (highest-MDCW <2000m) at inclusion were reevaluated after 6 months. Patients revascularized during the follow-up period were compared with reference patients (ie, with unchanged lifestyle medical or surgical status). Other patients (lost to follow-up or treatment change) were excluded (n = 89).We studied 44 revascularized and 39 reference patients. Changes in highest-MDCW (+442 vs. +13 m) and average-WSCW (+0.3 vs. -0.2 km h) were greater in revascularized than in reference patients (both P < 0.01). In contrast, no significant difference in average-DSCW changes was found between the groups. Among the revascularized patients, 13 (29.5%) had a change in average-WSCW, but not in highest-MDCW, greater than the mean + 1 standard deviation of the change observed for reference patients.Revascularization may improve highest-MDCW and/or average-WSCW. This first report of changes in community walking ability in revascularized patients suggests that, beyond measuring walking distances, average-WSCW measurement is essential to monitor these changes. Applicability to other surgical populations remains to be evaluated.

REGISTRATION

http://www.clinicaltrials.gov/ct2/show/NCT01141361.

摘要

未标注

血管重建术旨在改善间歇性跛行患者的行走能力。通过全球定位系统可以测量两个站点之间的最长测量距离(最高-MDCW)、平均步行速度(平均-WSCW)和平均停留时间(平均-DSCW),但血管重建术后它们的变化情况尚不清楚。

我们纳入了251例自述有间歇性跛行限制的外周动脉疾病患者。患者进行了一次1小时的散步,由全球定位系统接收器记录。纳入时确诊有行走限制(最高-MDCW<2000米)的患者(n = 172)在6个月后进行了重新评估。将随访期间接受血管重建术的患者与对照患者(即生活方式、药物治疗或手术状态未改变的患者)进行比较。排除其他患者(失访或治疗改变)(n = 89)。

我们研究了44例接受血管重建术的患者和39例对照患者。接受血管重建术的患者最高-MDCW(+442对+13米)和平均-WSCW(+0.3对-0.2千米/小时)的变化大于对照患者(P均<0.01)。相比之下,两组之间平均-DSCW变化无显著差异。在接受血管重建术的患者中,13例(29.5%)平均-WSCW有变化,但最高-MDCW无变化,其变化大于对照患者观察到的变化均值+1标准差。

血管重建术可能改善最高-MDCW和/或平均-WSCW。这是关于血管重建术后社区行走能力变化的首次报告,表明除了测量行走距离外,平均-WSCW测量对于监测这些变化至关重要。其在其他手术人群中的适用性仍有待评估。

注册信息

http://www.clinicaltrials.gov/ct2/show/NCT01141361

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048b/4602526/a69ca8a88263/medi-94-e838-g002.jpg

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