Hu Wei-Syun, Ting Wei-Jen, Chiang Wen-Dee, Pai Peiying, Yeh Yu-Lan, Chang Chung-Ho, Lin Wan-Teng, Huang Chih-Yang
PhD Program for Aging, China Medical University, Taichung 40402, Taiwan.
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
Int J Mol Sci. 2015 May 5;16(5):10158-72. doi: 10.3390/ijms160510158.
The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway.
肥胖在老年人中的患病率很高。碱性蛋白酶水解马铃薯蛋白（APPH），一种营养食品，可能比降血脂药物具有更大的益处且更经济。在本研究中，对用APPH（15、45和75毫克/千克/天）和普罗布考（500毫克/千克/天）治疗的高脂饮食（HFD）诱导的衰老大鼠高脂血症的血脂谱和心脏保护作用进行了评估。APPH治疗可将血清三酰甘油（TG）、总胆固醇（TC）和低密度脂蛋白（LDL）水平降至对照组所表达的正常水平。此外，在HFD衰老大鼠心脏中，APPH治疗（15和45毫克/千克/天）可重新激活IGF1R-PI3K-Akt存活途径，并抑制Fas-FADD（Fas相关死亡结构域）诱导的细胞凋亡。APPH（75毫克/千克/天）而非普罗布考（500毫克/千克/天）治疗可降低血脂而不影响高密度脂蛋白（HDL）表达。APPH对高脂血症衰老大鼠的心脏保护作用是通过降低血脂和增强代偿性IGF1R-PI3K-Akt存活途径的激活来实现的。
