Candrina R, Tosoni M
Recenti Prog Med. 1989 Sep;80(9):471-3.
We investigated a group of 26 patients with prolactin-secreting pituitary macroadenomas. Seventeen underwent neurosurgical operation alone, nine were also submitted to medical therapy with bromocriptine 7.5 mg/day, immediately after the operation. Patients presented similar clinical and biological characteristics. Fourteen patients without medical therapy showed a persistent hyperprolactinemia and the tumor recurred in 8 of these 17 patients. Of the 9 patients receiving medical and surgical therapy, only 1 presented persistent hyperlactinemia and none relapsed. Our results suggest that combined sequential surgical and medical therapy may be useful in the management of patients with prolactin-secreting pituitary macroadenomas.
我们对一组26例分泌催乳素的垂体大腺瘤患者进行了研究。17例仅接受了神经外科手术，9例在手术后立即还接受了每天7.5毫克溴隐亭的药物治疗。患者呈现出相似的临床和生物学特征。14例未接受药物治疗的患者出现持续性高催乳素血症，这17例患者中有8例肿瘤复发。在接受手术和药物联合治疗的9例患者中，只有1例出现持续性高催乳素血症，且无复发情况。我们的结果表明，序贯性手术和药物联合治疗可能对分泌催乳素的垂体大腺瘤患者的管理有用。
