Hamester U, Saeger W, Lüdecke D K
Department of Pathology, Marienkrankenhaus, Hamburg, FRG.
Histol Histopathol. 1987 Apr;2(2):135-42.
In order to study the light microscopical alterations of pituitary tumours under dopamine agonist treatment, three groups of a total of 18 large or small cell chromophobe adenomas were analysed by light microscopical, immunohistological and morphometrical methods. They were all removed by transsphenoidal surgery. 6 of them were treated preoperatively with dopamine agonists, bromocriptine and/or lisuride, for various periods of time. 8 adenomas remained preoperatively untreated. 4 additional untreated tumors were small cell inactive adenomas for comparison. One case was excluded from the final evaluation of the data because it appeared to be a typical non-responder, clinically as well as histologically. Immunohistological positivity for prolactin was to be found in all cases in various degrees. Clinically active adenomas contained many prolactin positive cells, whereas in inactive adenomas only scattered cells were prolactin positive. The morphometric analysis revealed a reduction of the cytoplasmic area in a statistically significant degree in the group of adenomas under treatment, which explains adequately the shrinkage of the entire adenoma and the reduction of prolactin plasma levels. The morphometric data of treated adenomas resembled those of untreated inactive adenomas.
为了研究多巴胺激动剂治疗下垂体肿瘤的光镜改变，采用光镜、免疫组织化学和形态计量学方法对三组共18例大细胞或小细胞嫌色性腺瘤进行了分析。所有肿瘤均经蝶窦手术切除。其中6例在术前接受了不同时间段的多巴胺激动剂（溴隐亭和/或麦角乙脲）治疗。8例腺瘤术前未接受治疗。另外4例未治疗的肿瘤为小细胞无功能腺瘤作为对照。有1例因在临床和组织学上均表现为典型的无反应者而被排除在最终数据评估之外。所有病例中均不同程度地发现催乳素免疫组织化学阳性。临床有功能腺瘤含有许多催乳素阳性细胞，而无功能腺瘤中仅有散在的细胞为催乳素阳性。形态计量学分析显示，治疗组腺瘤的细胞质面积在统计学上有显著减少，这充分解释了整个腺瘤的缩小以及血浆催乳素水平的降低。治疗腺瘤的形态计量学数据与未治疗的无功能腺瘤相似。
