Gräf Ralph, Batsios Petros, Meyer Irene
Universität Potsdam, Institut für Biochemie und Biologie, Karl-Liebknecht-Strasse 24-25, Ha…, 14476 Potsdam-Golm, Germany.
Universität Potsdam, Institut für Biochemie und Biologie, Karl-Liebknecht-Strasse 24-25, Ha…, 14476 Potsdam-Golm, Germany.
Eur J Cell Biol. 2015 Jun;94(6):249-56. doi: 10.1016/j.ejcb.2015.04.004. Epub 2015 Apr 28.
The current eukaryotic tree of life groups most eukaryotes into one of five supergroups, the Opisthokonta, Amoebozoa, Archaeplastida, Excavata and SAR (Stramenopile, Alveolata, Rhizaria). Molecular and comparative morphological analyses revealed that the last eukaryotic common ancestor (LECA) already contained a rather sophisticated equipment of organelles including a mitochondrion, an endomembrane system, a nucleus with a lamina, a microtubule-organizing center (MTOC), and a flagellar apparatus. Recent studies of MTOCs, basal bodies/centrioles, and nuclear envelope organization of organisms in different supergroups have clarified our picture of how the nucleus and MTOCs co-evolved from LECA to extant eukaryotes. In this review we summarize these findings with special emphasis on valuable contributions of research on a lamin-like protein, nuclear envelope proteins, and the MTOC in the amoebozoan model organism Dictyostelium discoideum.
后鞭毛生物超群、变形虫超群、古质体超群、挖掘超群和SAR（不等鞭毛类、囊泡虫类、有孔虫类）。分子和比较形态学分析表明，最后的真核生物共同祖先（LECA）已经拥有一套相当复杂的细胞器，包括线粒体、内膜系统、有核纤层的细胞核、微管组织中心（MTOC）和鞭毛装置。最近对不同超群生物的MTOC、基体/中心粒和核膜组织的研究，使我们对细胞核和MTOC如何从LECA共同进化到现存真核生物有了更清晰的认识。在这篇综述中，我们总结了这些发现，并特别强调了对变形虫模式生物盘基网柄菌中类核纤层蛋白、核膜蛋白和MTOC的研究所做出的宝贵贡献。
