肽YY对大鼠胃酸分泌的抑制作用。

Inhibitory effect of peptide YY on gastric acid output in rats.

作者信息

Hashimoto Y, Sano I, Nagahata Y, Wang Z T, Itoh A, Takeda K, Ichihara T, Moritomo H, Urakawa T, Saitoh Y

机构信息

First Department of Surgery, Kobe University School of Medicine, Japan.

出版信息

Scand J Gastroenterol Suppl. 1989;162:134-7. doi: 10.3109/00365528909091144.

DOI:10.3109/00365528909091144

PMID:2595285

Abstract

The administration of peptide YY (PYY: 0.8, 1.6 and 3.2 nmol/kg/h, i.v.) to fasting rats inhibited not only baclofen (2 mg/kg, s.c.)-stimulated gastric acid output and gastric mucosal blood flow, but also pentagastrin (8 micrograms/kg/h, i.v.)-stimulated gastric acid output. PYY (3.2 nmol/kg/h) reduced baclofen-induced acid output more than pentagastrin-induced acid output, i.e., by 61.8 +/- 11.5% compared to 35.3 +/- 8.2%. PYY inhibited acetylcholine (ACh) release from cholinergic nerve endings of gastric body evoked by electrical transmural stimulation (ETS: 1 msec, 10 V, 3 Hz, 30 sec) by 47.2 +/- 3.5%. The mechanism of the inhibitory effect of PYY on gastric acid output seems to involve decreased gastric mucosal blood flow and reduced ACh release from cholinergic nerves.

摘要

给禁食大鼠静脉注射肽YY（PYY：0.8、1.6和3.2 nmol/kg/h）不仅抑制了巴氯芬（2 mg/kg，皮下注射）刺激的胃酸分泌和胃黏膜血流量，还抑制了五肽胃泌素（8 μg/kg/h，静脉注射）刺激的胃酸分泌。PYY（3.2 nmol/kg/h）对巴氯芬诱导的胃酸分泌的抑制作用大于对五肽胃泌素诱导的胃酸分泌的抑制作用，即分别为61.8±11.5%和35.3±8.2%。PYY抑制了经壁电刺激（ETS：1毫秒，10伏，3赫兹，30秒）诱发的胃体胆碱能神经末梢乙酰胆碱（ACh）释放，抑制率为47.2±3.5%。PYY对胃酸分泌的抑制作用机制似乎涉及胃黏膜血流量减少和胆碱能神经释放ACh减少。