肽YY对胃酸分泌的抑制作用。

Inhibitory action of peptide YY on gastric acid secretion.

作者信息

Guo Y S, Fujimura M, Lluis F, Tsong Y, Greeley G H, Thompson J C

出版信息

Am J Physiol. 1987 Sep;253(3 Pt 1):G298-302. doi: 10.1152/ajpgi.1987.253.3.G298.

DOI:10.1152/ajpgi.1987.253.3.G298

Abstract

The purpose of this study is to investigate the effect of peptide YY (PYY) on pentagastrin-, histamine-, and bethanechol-stimulated gastric acid secretion and the possible mechanisms by which PYY inhibits gastric acid secretion. Six mongrel dogs with chronic gastric and duodenal fistulas were given an intravenous infusion of pentagastrin (0.5 microgram . kg-1 . h-1), histamine (18 micrograms . kg-1 . h-1), or bethanechol (80 micrograms . kg-1 . h-1) either alone or simultaneously with intravenous PYY (100, 200, 400, pmol . kg-1 . h-1). PYY (100, 200, 400 pmol . kg-1 . h-1) inhibited pentagastrin-stimulated gastric acid secretion in a dose-dependent manner. PYY (400 pmol . kg-1 . h-1) did not depress bethanechol-stimulated gastric acid secretion. PYY (400 pmol . kg-1 . h-1) also failed to inhibit histamine-stimulated gastric acid secretion. Furthermore, PYY inhibit pentagastrin-stimulated gastric acid secretion in the face of atropine, vagotomy, or indomethacin treatment. These findings indicate that the inhibitory action of PYY on gastric acid secretion is in part independent of long and short cholinergic pathways. These findings also indicate that the inhibitory mechanism of PYY is independent of prostaglandin synthesis. Our findings are discussed in relation to previous reports regarding the effects of PYY on gastric acid secretion.

摘要

本研究的目的是探讨肽YY（PYY）对五肽胃泌素、组胺和氨甲酰甲胆碱刺激的胃酸分泌的影响，以及PYY抑制胃酸分泌的可能机制。给6只患有慢性胃和十二指肠瘘的杂种犬静脉输注五肽胃泌素（0.5微克·千克⁻¹·小时⁻¹）、组胺（18微克·千克⁻¹·小时⁻¹）或氨甲酰甲胆碱（80微克·千克⁻¹·小时⁻¹），单独或同时静脉输注PYY（100、200、400皮摩尔·千克⁻¹·小时⁻¹）。PYY（100、200、400皮摩尔·千克⁻¹·小时⁻¹）以剂量依赖的方式抑制五肽胃泌素刺激的胃酸分泌。PYY（400皮摩尔·千克⁻¹·小时⁻¹）不抑制氨甲酰甲胆碱刺激的胃酸分泌。PYY（400皮摩尔·千克⁻¹·小时⁻¹）也未能抑制组胺刺激的胃酸分泌。此外，在阿托品、迷走神经切断术或吲哚美辛治疗的情况下，PYY仍能抑制五肽胃泌素刺激的胃酸分泌。这些发现表明，PYY对胃酸分泌的抑制作用部分独立于长、短胆碱能途径。这些发现还表明，PYY的抑制机制独立于前列腺素合成。我们的研究结果结合先前关于PYY对胃酸分泌影响的报告进行了讨论。