Velho-Pereira S, Noronha A, Mathias A, Zakane R, Naik V, Naik P, Salker A V, Naik S R
Department of Biotechnology, St. Xavier's College, Goa, India.
Department of Chemistry, Goa University, Goa, India.
Mater Sci Eng C Mater Biol Appl. 2015;52:282-7. doi: 10.1016/j.msec.2015.03.046. Epub 2015 Mar 25.
The bactericidal effect of pristine and doped cobalt ferrite nanoparticles has been evaluated against multiple drug resistant clinical strains by assessing the number of colony-forming units (CFU). Monophasic polycrystalline ferrites have been prepared by the malate-glycolate sol-gel autocombustion method as confirmed by the X-ray diffraction study. Various changes occurring during the preparative stages have been demonstrated using TG-DTA analysis which is well complemented by the FTIR spectroscopy. The antibacterial studies carried out demonstrate a bactericidal effect of the nanoparticles wherein the number of CFU has been found to decrease with doping. Cellular distortions have been revealed through SEM. Variation in the number of CFU with dopant type has also been reported herein.
通过评估菌落形成单位（CFU）的数量，已对原始和掺杂的钴铁氧体纳米颗粒对多重耐药临床菌株的杀菌效果进行了评估。如X射线衍射研究所证实的，已通过苹果酸 - 乙醇酸溶胶 - 凝胶自燃烧法制备了单相多晶铁氧体。使用TG-DTA分析证明了制备阶段发生的各种变化，FTIR光谱对其进行了很好的补充。所进行的抗菌研究证明了纳米颗粒的杀菌效果，其中发现CFU的数量随着掺杂而减少。通过扫描电子显微镜（SEM）揭示了细胞变形。本文还报道了CFU数量随掺杂剂类型的变化。
