YuPeng Liu, YuXue Zhang, PengFei Li, Cheng Cheng, YaShuang Zhao, DaPeng Li, Chen Du
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Department of Preventive Medicine, School of Public Health, Harbin Medical University, Harbin, China.
Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1086-93. doi: 10.1158/1055-9965.EPI-14-1329. Epub 2015 May 7.
As a neutral lipid and prominent component of the Western diet, cholesterol levels might be a risk factor for prostate cancer. However, current evidence has been inconsistent. This meta-analysis aimed to evaluate the association between blood cholesterol levels and the risk of prostate cancer.
An extensive search was performed in MEDLINE and EMBASE for prospective studies that have reported the association between total cholesterol (TC), high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL) levels in blood and risk of prostate cancer. Random-effects models were used to summarize the study-specific results.
Fourteen studies were included in this meta-analysis. In the meta-analysis, the summarized risk ratios (RR) for the highest to lowest cholesterol levels were as follows: 1.05 [95% confidence interval (CI), 0.97-1.14; P = 0.21] for TC, 0.93 (95% CI, 0.80-1.10; P = 0.40) for HDL, and 1.17 (95% CI, 0.88-1.55; P = 0.51) for LDL. When restricting to high-grade prostate cancer, the pooled RR was 1.32 (95% CI, 0.93-1.87; P = 0.13) for TC. In dose-response analyses, a 1 mmol/L increment in blood TC, HDL, and LDL level conferred an RR of 1.01 (95% CI, 0.99-1.02; P = 0.38), 0.98 (95% CI, 0.91-1.07; P = 0.72), and 1.04 (95% CI, 0.98-1.10; P = 0.24), respectively.
In this meta-analysis of 14 large prospective studies, blood TC, HDL, and LDL levels were not associated with the risk of either overall prostate cancer or high-grade prostate cancer.
Our findings did not appear to support the hypothesis that hypercholesterolemia increases the risk of prostate cancer.
作为西方饮食中的一种中性脂质和主要成分，胆固醇水平可能是前列腺癌的一个风险因素。然而，目前的证据并不一致。这项荟萃分析旨在评估血液胆固醇水平与前列腺癌风险之间的关联。
在MEDLINE和EMBASE中进行了广泛检索，以查找报告血液中总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）和低密度脂蛋白胆固醇（LDL）水平与前列腺癌风险之间关联的前瞻性研究。采用随机效应模型汇总各研究的具体结果。
本荟萃分析纳入了14项研究。在荟萃分析中，胆固醇水平从最高到最低的汇总风险比（RR）如下：TC为1.05 [95%置信区间（CI），0.97 - 1.14；P = 0.21]，HDL为0.93（95% CI，0.80 - 1.10；P = 0.40），LDL为1.17（95% CI，0.88 - 1.55；P = 0.51）。当仅限于高级别前列腺癌时，TC的合并RR为1.32（95% CI，0.93 - 1.87；P = 0.13）。在剂量反应分析中，血液TC、HDL和LDL水平每增加1 mmol/L，RR分别为1.01（95% CI，0.99 - 1.02；P = 0.38）、0.98（95% CI，0.91 - 1.07；P = 0.72）和1.04（95% CI，0.98 - 1.10；P = 0.24）。
在这项对14项大型前瞻性研究的荟萃分析中，血液TC、HDL和LDL水平与总体前列腺癌或高级别前列腺癌的风险均无关联。
我们的研究结果似乎不支持高胆固醇血症会增加前列腺癌风险这一假设。
