School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Chem Soc Rev. 2015 Aug 7;44(15):5220-45. doi: 10.1039/c4cs00467a. Epub 2015 May 8.
Radical aryl migration reactions are of particular interest to the chemical community due to their potential application in radical chemistry and organic synthesis. The neophyl rearrangements used as radical clocks for examining the radical-molecular reactions have been known for decades. The combinations of these migrations with other radical reactions have provided a wide range of novel synthetic methodologies that are complementary to nucleophilic rearrangements. This review will give an overview of various types of radical aryl migrations, with an emphasis on their mechanistic studies from a historical point of view, as well as their application in tandem radical reactions.
芳基自由基迁移反应因其在自由基化学和有机合成中的潜在应用而受到化学界的特别关注。作为研究自由基-分子反应的自由基钟的新菲基重排已经存在了几十年。这些迁移与其他自由基反应的结合提供了广泛的新型合成方法，这些方法与亲核重排互补。本综述将概述各种类型的芳基自由基迁移反应，重点从历史角度讨论其机理研究，以及它们在串联自由基反应中的应用。
