Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA.
Nanomedicine (Lond). 2015;10(8):1275-88. doi: 10.2217/nnm.14.205.
To investigate whether cerium oxide (CeO2) nanoparticles could be used for the treatment of severe sepsis.
MATERIALS & METHODS: Cecal peritonitis was induced in male Sprague-Dawley rats in the presence and absence of CeO2 nanoparticles. Cultured macrophages (RAW264.7 cells) were challenged with lipopolysaccharide in the absence and presence of CeO2 nanoparticles. The effect of nanoparticles on the growth of Escherichia coli and Staphylococcus aureus was determined in culture.
Nanoparticle treatment decreased sepsis-induced mortality, organ damage, serum IL-6, blood urea nitrogen and inflammatory markers. Nanoparticle treatment diminished lipopolysaccharide-induced cytokine release and p65-nuclear factor-KB (NF-KB) activation in cultured RAW264.7 cells. Exposure to CeO2 nanoparticles inhibited E. coli growth.
The findings of this study indicate that CeO2 nanoparticles may be useful for the treatment of sepsis.
研究氧化铈（CeO2）纳米粒子是否可用于治疗严重败血症。
在雄性 Sprague-Dawley 大鼠中诱导盲肠腹膜炎，同时存在和不存在 CeO2 纳米粒子。在不存在和存在 CeO2 纳米粒子的情况下，用脂多糖刺激培养的巨噬细胞（RAW264.7 细胞）。在培养物中测定纳米粒子对大肠杆菌和金黄色葡萄球菌生长的影响。
纳米粒子治疗降低了败血症诱导的死亡率、器官损伤、血清白细胞介素 6、血尿素氮和炎症标志物。纳米粒子治疗减弱了脂多糖诱导的培养 RAW264.7 细胞中细胞因子释放和 p65-核因子-KB（NF-KB）激活。暴露于 CeO2 纳米粒子抑制了大肠杆菌的生长。
本研究结果表明，CeO2 纳米粒子可能对败血症的治疗有用。
