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纳米技术在脓毒症治疗中的进展、挑战与未来前景

Advancements, Challenges, and Future Prospects of Nanotechnology in Sepsis Therapy.

作者信息

Liu Yukun, Liu Jiafeng, Wang Dongfang, Xu Ligang, Li Zhanfei, Bai Xiangjun, Zhu Hao, Wang Yuchang

机构信息

Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

出版信息

Int J Nanomedicine. 2025 Jun 16;20:7685-7714. doi: 10.2147/IJN.S488026. eCollection 2025.

DOI:10.2147/IJN.S488026
PMID:40546802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12180596/
Abstract

Sepsis is a life-threatening systemic inflammatory syndrome, typically triggered by infection, that can lead to multi-organ failure and high mortality rates. Traditional treatments for sepsis often have limited efficacy and significant side effects, necessitating the exploration of innovative therapeutic strategies. In recent years, the application of nanotechnology in sepsis therapy has garnered widespread attention due to its potential to modulate immune responses, reduce inflammation and oxidative stress, and eliminate bacterial toxins. This review aims to provide an overview of the latest advancements, challenges, and future prospects of nanotechnology in sepsis treatment. By analyzing recent developments in anti-inflammatory, immunomodulatory, antioxidant, and detoxification applications of nanotechnology, key findings and therapeutic potential are summarized, including the use of nanocarriers, biomimetic nanoparticles, and self-assembled nanomaterials. Furthermore, this review addresses the challenges in clinical translation, such as drug targeting, long-term safety, and biocompatibility. Future research will require large-scale clinical trials and interdisciplinary collaboration to validate the efficacy of nanotechnology in sepsis treatment and facilitate its integration into clinical practice. Overall, nanotechnology presents unprecedented opportunities for sepsis management, and this review seeks to offer insights into ongoing research while promoting further advancements in this field.

摘要

脓毒症是一种危及生命的全身性炎症综合征，通常由感染引发，可导致多器官功能衰竭和高死亡率。脓毒症的传统治疗方法往往疗效有限且副作用显著，因此有必要探索创新的治疗策略。近年来，纳米技术在脓毒症治疗中的应用因其具有调节免疫反应、减轻炎症和氧化应激以及清除细菌毒素的潜力而受到广泛关注。本综述旨在概述纳米技术在脓毒症治疗方面的最新进展、挑战和未来前景。通过分析纳米技术在抗炎、免疫调节、抗氧化和解毒应用方面的最新进展，总结了关键发现和治疗潜力，包括纳米载体、仿生纳米颗粒和自组装纳米材料的使用。此外，本综述还讨论了临床转化中的挑战，如药物靶向性、长期安全性和生物相容性。未来的研究将需要大规模临床试验和跨学科合作，以验证纳米技术在脓毒症治疗中的疗效，并促进其融入临床实践。总体而言，纳米技术为脓毒症管理带来了前所未有的机遇，本综述旨在提供对正在进行的研究的见解，同时推动该领域的进一步发展。

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本文引用的文献

1
The Interplay between Antibiotics and the Host Immune Response in Sepsis: From Basic Mechanisms to Clinical Considerations: A Comprehensive Narrative Review.脓毒症中抗生素与宿主免疫反应的相互作用：从基本机制到临床考量：一篇全面的叙述性综述
Antibiotics (Basel). 2024 Apr 28;13(5):406. doi: 10.3390/antibiotics13050406.
2
Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23.脓毒症和脓毒性休克患者的辅助免疫治疗药物：23位专家的多学科共识
J Anesth Analg Crit Care. 2024 Apr 30;4(1):28. doi: 10.1186/s44158-024-00165-3.
3
Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis.
肽在用于诊断和治疗细菌性败血症的纳米系统中的应用。
J Biomed Sci. 2024 Apr 19;31(1):40. doi: 10.1186/s12929-024-01029-2.
4
ROS Balance Autoregulating Core-Shell CeO@ZIF-8/Au Nanoplatform for Wound Repair.用于伤口修复的ROS平衡自调节核壳CeO@ZIF-8/Au纳米平台
Nanomicro Lett. 2024 Mar 21;16(1):156. doi: 10.1007/s40820-024-01353-0.
5
Navigating the Cytokine Storm: A Comprehensive Review of Chemokines and Cytokines in Sepsis.应对细胞因子风暴：脓毒症中趋化因子和细胞因子的全面综述
Cureus. 2024 Feb 15;16(2):e54275. doi: 10.7759/cureus.54275. eCollection 2024 Feb.
6
Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy.刺激响应水凝胶作为炎症靶向治疗的药物传递系统。
Adv Sci (Weinh). 2024 Jan;11(1):e2306152. doi: 10.1002/advs.202306152. Epub 2023 Nov 20.
7
Recent advances and prospects in nanomaterials for bacterial sepsis management.纳米材料在细菌性败血症管理中的最新进展与展望。
J Mater Chem B. 2023 Nov 22;11(45):10778-10792. doi: 10.1039/d3tb02220j.
8
Natural Extracts for Antibacterial Applications.天然提取物在抗菌应用中的作用。
Small. 2024 Mar;20(9):e2306553. doi: 10.1002/smll.202306553. Epub 2023 Oct 17.
9
Bacterial Toxin-Antitoxin Systems' Cross-Interactions-Implications for Practical Use in Medicine and Biotechnology.细菌毒素-抗毒素系统的交叉相互作用——在医学和生物技术实际应用中的意义。
Toxins (Basel). 2023 Jun 4;15(6):380. doi: 10.3390/toxins15060380.
10
From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.从细菌毒素到治疗剂：类鼻疽酮的意外命运。
Toxins (Basel). 2023 May 30;15(6):369. doi: 10.3390/toxins15060369.