Anthropology Department and Human Biology Program, Indiana University, Bloomington, IN, USA.
Kamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Eur J Clin Nutr. 2018 Apr;72(4):564-571. doi: 10.1038/s41430-018-0108-z. Epub 2018 Feb 16.
BACKGROUND/OBJECTIVES: To ascertain associations between plasma insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3) and their molar ratio at 2 y with neonatal size, infant growth, body composition at 2 y, and feeding practices in an Indian cohort.
SUBJECTS/METHODS: A cohort of 209 newborns, with 122 followed at 2 y. Anthropometry was conducted at birth and 2 y. IGF-I and IGFBP-3 concentrations were measured in cord blood and at 2 y. Maternal and child diet was assessed by food frequency questionnaires and maternal interviews. Multivariate regression was used to test for associations adjusting for confounding factors.
Mean 2 y plasma IGF-I and IGFBP-3 concentrations and IGF-I/IGFBP-3 were 49.4 ng/ml (95% CI: 44.1, 54.8), 1953.8 ng/ml (CI: 1870.6, 2036.9) ng/ml, and 0.088 (CI: 0.081, 0.095), respectively. IGF-I and IGF-I/IGFBP-3 were positively associated with current length, but not body mass index or adiposity. IGF-I was higher among those with greater change in length since birth. IGF-I concentrations were higher in children who drank the most milk (>500 vs. <250 ml per day: 65.6 vs. 42.8 ng/ml, p < 0.04), received other milk <6 months compared to ≥6 months (56.3 vs. 44.8 ng/ml, p < 0.05), and in those whose mothers consumed milk daily vs. less frequently in late pregnancy (56.4 vs. 42.7 ng/ml, p < 0.01). In multivariate regression, 2 y IGF-I concentration and IGF-I/IGFBP-3 were each positively associated with current length and milk intake. IGFBP-3 was not related to anthropometry or milk intake.
Plasma IGF-I concentrations and IGF-I/IGFBP-3 at 2 y are positively associated with length at 2 y and current milk intake.
背景/目的：在印度队列中，确定出生后 2 年血浆胰岛素样生长因子 I（IGF-I）、胰岛素样生长因子结合蛋白 3（IGFBP-3）及其摩尔比与新生儿大小、婴儿生长、2 岁时身体成分和喂养方式之间的关系。
受试者/方法：209 名新生儿的队列，其中 122 名在 2 岁时随访。在出生和 2 岁时进行人体测量学检查。在脐带血和 2 岁时测量 IGF-I 和 IGFBP-3 浓度。通过食物频率问卷和母亲访谈评估母婴饮食。使用多元回归检验调整混杂因素后的关联。
平均 2 岁时血浆 IGF-I 和 IGFBP-3 浓度和 IGF-I/IGFBP-3 分别为 49.4ng/ml（95%CI：44.1，54.8）、1953.8ng/ml（CI：1870.6，2036.9）ng/ml 和 0.088（CI：0.081，0.095）。IGF-I 和 IGF-I/IGFBP-3 与当前身长呈正相关，但与体重指数或肥胖无关。出生以来身长变化较大的婴儿 IGF-I 水平较高。与每天饮用牛奶量>500ml（65.6ng/ml 比 42.8ng/ml，p<0.04）和<250ml（56.3ng/ml 比 44.8ng/ml，p<0.05）相比，饮用牛奶最多的儿童 IGF-I 浓度较高，在 6 个月内接受其他牛奶的儿童 IGF-I 浓度较高，以及在母亲在妊娠后期每天食用牛奶的儿童与不经常食用的儿童（56.4ng/ml 比 42.7ng/ml，p<0.01）相比。多元回归分析显示，2 岁时 IGF-I 浓度和 IGF-I/IGFBP-3 均与当前身高和牛奶摄入量呈正相关。IGFBP-3 与人体测量学或牛奶摄入量无关。
2 岁时的血浆 IGF-I 浓度和 IGF-I/IGFBP-3 与 2 岁时的身高和当前的牛奶摄入量呈正相关。
