Gong Jian, Cao Juan, Liu Guinan, Huo Ji-Rong
Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Int J Oncol. 2015 Jul;47(1):43-50. doi: 10.3892/ijo.2015.2983. Epub 2015 May 4.
Gastric cancer (GC) is one of the commonest cancers with high mortality. Despite improvement in early detection and treatments, the outcome of advanced GC remains unsatisfactory due to the poor understanding of the intricate pathogenesis of GC. GC is a multifactorial and multistep disease which involves activation of oncogenes and inactivation of tumor suppressor genes. Ubiquitin proteasome system (UPS) catalyzing many critical protein substrates is involved in initiation and development of cancer. F-box proteins (FBPs) are the main functional components of UPS. Accumulated evidence strongly suggests that abnormal regulations of FBPs contribute to uncontrolled proliferation, genomic instability and cancer. In this review, we discuss how the dysregulated FBPs promote the occurrence and development of GC.
胃癌（GC）是最常见且死亡率高的癌症之一。尽管早期检测和治疗有所改善，但由于对GC复杂发病机制的了解不足，晚期GC的治疗效果仍不尽人意。GC是一种多因素、多步骤的疾病，涉及癌基因的激活和抑癌基因的失活。催化许多关键蛋白质底物的泛素蛋白酶体系统（UPS）参与癌症的发生和发展。F-box蛋白（FBPs）是UPS的主要功能成分。越来越多的证据有力地表明，FBPs的异常调节会导致不受控制的增殖、基因组不稳定和癌症。在这篇综述中，我们讨论了失调的FBPs如何促进GC的发生和发展。
