非编码 RNA 调控人类癌症中的 F-box 蛋白。

Regulation of F-box proteins by noncoding RNAs in human cancers.

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

出版信息

Cancer Lett. 2019 Dec 1;466:61-70. doi: 10.1016/j.canlet.2019.09.008. Epub 2019 Sep 20.

DOI:10.1016/j.canlet.2019.09.008

PMID:31546023

Abstract

F-box proteins (FBPs) are proteins containing an F-box domain and are one of three subunits in SKP1-Cullin1-F-box protein (SCF) E3 ligase complexes. Accumulated evidence has shown that FBP regulates tumorigenesis and the progression of human cancer via ubiquitination and degradation of downstream substrates, which can be oncoproteins or tumor suppressors. Emerging evidence has revealed that noncoding RNAs (ncRNAs) govern the expression of FBP in human cancers. Specifically, microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been shown to govern FBP expression in malignancies. Therefore, in this review article, we discuss how miRNAs target FBPs and participate in tumorigenesis and tumor progression. Moreover, we briefly highlight the role of lncRNAs and circRNAs in the regulation of FBPs in cancer. Therefore, targeting ncRNAs could be a novel approach to regulate FBPs for anticancer therapy.

摘要

F-box 蛋白（FBPs）是一类含有 F-box 结构域的蛋白，是 SKP1-Cullin1-F-box 蛋白（SCF）E3 连接酶复合物的三个亚基之一。大量证据表明，FBP 通过泛素化和降解下游底物（可作为癌蛋白或肿瘤抑制因子）来调节肿瘤发生和人类癌症的进展。新出现的证据表明，非编码 RNA（ncRNA）可调控人类癌症中 FBP 的表达。具体而言，已经表明 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）和环状 RNA（circRNAs）可调控恶性肿瘤中 FBP 的表达。因此，在这篇综述文章中，我们讨论了 miRNA 如何靶向 FBP 并参与肿瘤发生和肿瘤进展。此外，我们还简要强调了 lncRNA 和 circRNA 在调控癌症中 FBP 方面的作用。因此，针对 ncRNA 可能是一种用于抗癌治疗的调节 FBP 的新方法。