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胶体药物递送系统:现状与未来方向

Colloidal drug delivery systems: current status and future directions.

作者信息

Garg Tarun, Rath Goutam, Goyal Amit Kumar

机构信息

Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 09501223252(M); Punjab Technical University, Kapurthala, Punjab, India.

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Punjab Technical University, Kapurthala, Punjab, India.

出版信息

Crit Rev Ther Drug Carrier Syst. 2015;32(2):89-147. doi: 10.1615/critrevtherdrugcarriersyst.2015010159.

Abstract

In this paper, we provide an overview an extensive range of colloidal drug delivery systems with special focus on vesicular and particulates systems that are being used in research or might be potentially useful as carriers systems for drug or active biomolecules or as cell carriers with application in the therapeutic field. We present some important examples of commercially available drug delivery systems with applications in research or in clinical fields. This class of systems is widely used due to excellent drug targeting, sustained and controlled release behavior, higher entrapment efficiency of drug molecules, prevention of drug hydrolysis or enzymatic degradation, and improvement of therapeutic efficacy. These characteristics help in the selection of suitable carrier systems for drug, cell, and gene delivery in different fields.

摘要

在本文中,我们概述了广泛的胶体药物递送系统,特别关注囊泡和颗粒系统,这些系统正在研究中使用,或者可能作为药物或活性生物分子的载体系统,或作为在治疗领域有应用的细胞载体潜在有用。我们展示了一些在研究或临床领域有应用的市售药物递送系统的重要例子。这类系统因出色的药物靶向性、持续和控释行为、药物分子的更高包封效率、防止药物水解或酶降解以及提高治疗效果而被广泛使用。这些特性有助于在不同领域选择适合药物、细胞和基因递送的载体系统。

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