Simondi Daniele, Ribaldone Davide Giuseppe, Bonagura Gabriele Antonio, Foi Simona, Sapone Nicoletta, Garavagno Marco, Villanacci Vincenzo, Bernardi Davide, Pellicano Rinaldo, Rizzetto Mario, Astegiano Marco
Department of Gastroenterology and Hepatology, Molinette Hospital, SGAS, Via Cavour 31, 10123 Torino, Italy.
Department of Gastroenterology and Hepatology, Molinette Hospital, SGAS, Via Cavour 31, 10123 Torino, Italy.
Clin Res Hepatol Gastroenterol. 2015 Dec;39(6):740-5. doi: 10.1016/j.clinre.2015.03.005. Epub 2015 May 5.
Helicobacter pylori (H. pylori) infection influences duodenal inflammation. Consequently, in celiac disease and in duodenal intraepithelial lymphocytosis, the bacterium could affect the clinical-histological manifestations. The aim of this work was to evaluate the prevalence and the potential role of H. pylori infection in celiac disease and duodenal intraepithelial lymphocytosis.
H. pylori status was reviewed in 154 patients with celiac disease or duodenal intraepithelial lymphocytosis and in a control population. This retrospective study was performed at Molinette hospital, university of Torino, Italy.
H. pylori prevalence was 36% in celiac disease patients, 19% in case of duodenal intraepithelial lymphocytosis and 41% in controls (P<0.05 vs. duodenal intraepithelial lymphocytosis). H. pylori prevalence was not significantly different between celiac disease patients with or without iron deficiency anemia (22% vs. 39%) and it was higher in patients with milder duodenal lesions: 50% in Marsh-Oberhuber classification type 1-2 vs. 33% in type 3. Celiac disease patients had a mean intraepithelial lymphocytes count greater than that of duodenal intraepithelial lymphocytosis patients (52 vs. 44 intraepithelial lymphocytes per 100 epithelial cells). Both in celiac disease and in duodenal intraepithelial lymphocytosis patients, H. pylori infection was associated with an increase in intraepithelial lymphocytes count, but this difference was not significant.
H. pylori prevalence was similar in celiac disease patients and in controls and higher in patients with milder duodenal lesions. There was no association between H. pylori infection and duodenal intraepithelial lymphocytosis.
幽门螺杆菌（H. pylori）感染会影响十二指肠炎症。因此，在乳糜泻和十二指肠上皮内淋巴细胞增多症中，该细菌可能会影响临床组织学表现。本研究的目的是评估H. pylori感染在乳糜泻和十二指肠上皮内淋巴细胞增多症中的患病率及其潜在作用。
回顾性分析了154例乳糜泻或十二指肠上皮内淋巴细胞增多症患者以及对照组人群的H. pylori感染状况。该研究在意大利都灵大学莫利内特医院进行。
乳糜泻患者中H. pylori感染率为36%，十二指肠上皮内淋巴细胞增多症患者中为19%，对照组中为41%（与十二指肠上皮内淋巴细胞增多症患者相比，P<0.05）。有无缺铁性贫血的乳糜泻患者中H. pylori感染率无显著差异（分别为22%和39%），十二指肠病变较轻的患者中感染率更高：马什-奥伯胡伯分类1-2型患者中为50%，3型患者中为33%。乳糜泻患者的上皮内淋巴细胞平均计数高于十二指肠上皮内淋巴细胞增多症患者（每100个上皮细胞中分别为52个和44个上皮内淋巴细胞）。在乳糜泻和十二指肠上皮内淋巴细胞增多症患者中，H. pylori感染均与上皮内淋巴细胞计数增加有关，但差异不显著。
乳糜泻患者和对照组中H. pylori感染率相似，十二指肠病变较轻的患者中感染率更高。H. pylori感染与十二指肠上皮内淋巴细胞增多症之间无关联。
