Bosch Dustin E, Liu Yong-Jun, Truong Camtu D, Lloyd Kelly A, Swanson Paul E, Upton Melissa P, Yeh Matthew M
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, 1959 NE Pacific Street, NE140D, Box 356100, Seattle, WA, 98195-6100, USA.
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Virchows Arch. 2021 Apr;478(4):805-809. doi: 10.1007/s00428-020-02941-2. Epub 2020 Oct 6.
Our aims were to assess performance of duodenal intraepithelial lymphocyte counting for diagnosis of Helicobacter pylori (H. pylori) gastritis, and effects of eradication therapy on intraepithelial lymphocytosis. Paired duodenal and gastric biopsies from subjects with a pathologic diagnosis of H. pylori gastritis were reviewed. Higher duodenal intraepithelial lymphocyte counts were observed in 40 subjects with H. pylori gastritis (26 ± 5 per villus) than 52 subjects negative for H. pylori (12 ± 2 per villus). After successful eradication therapy, duodenal lymphocytes were indistinguishable from H. pylori-negative subjects, whereas they remained elevated after failed eradication therapy. This study confirms previous reports of increased duodenal intraepithelial lymphocytes in patients with concurrent Helicobacter pylori gastritis. Intraepithelial lymphocyte counts of > 15 per villus or > 10 per 100 enterocytes were predictive of infection. Duodenal lymphocytosis decreases significantly after successful eradication therapy but remains elevated when treatment fails.
我们的目的是评估十二指肠上皮内淋巴细胞计数对幽门螺杆菌（H. pylori）胃炎诊断的性能，以及根除治疗对上皮内淋巴细胞增多症的影响。对经病理诊断为H. pylori胃炎的受试者的配对十二指肠和胃活检组织进行了回顾。40例H. pylori胃炎患者的十二指肠上皮内淋巴细胞计数（每绒毛26±5个）高于52例H. pylori阴性患者（每绒毛12±2个）。成功根除治疗后，十二指肠淋巴细胞与H. pylori阴性受试者无差异，而根除治疗失败后其仍保持升高。本研究证实了先前关于并发幽门螺杆菌胃炎患者十二指肠上皮内淋巴细胞增多的报道。每绒毛上皮内淋巴细胞计数>15个或每100个肠上皮细胞>10个可预测感染。成功根除治疗后十二指肠淋巴细胞增多症显著降低，但治疗失败时仍保持升高。
