• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

神经影像学与焦虑:病理性和非病理性焦虑的神经基础

Neuroimaging and Anxiety: the Neural Substrates of Pathological and Non-pathological Anxiety.

作者信息

Taylor James M, Whalen Paul J

机构信息

Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH, 03755, USA,

出版信息

Curr Psychiatry Rep. 2015 Jun;17(6):49. doi: 10.1007/s11920-015-0586-9.

DOI:10.1007/s11920-015-0586-9
PMID:25957101
Abstract

Advances in the use of noninvasive neuroimaging to study the neural correlates of pathological and non-pathological anxiety have shone new light on the underlying neural bases for both the development and manifestation of anxiety. This review summarizes the most commonly observed neural substrates of the phenotype of anxiety. We focus on the neuroimaging paradigms that have shown promise in exposing this relevant brain circuitry. In this way, we offer a broad overview of how anxiety is studied in the neuroimaging laboratory and the key findings that offer promise for future research and a clearer understanding of anxiety.

摘要

使用非侵入性神经成像技术研究病理性和非病理性焦虑的神经关联取得的进展,为焦虑的发展和表现的潜在神经基础带来了新的认识。本综述总结了焦虑表型中最常观察到的神经基质。我们关注那些在揭示这一相关脑回路方面显示出前景的神经成像范式。通过这种方式,我们对神经成像实验室中如何研究焦虑以及为未来研究和更清晰地理解焦虑带来希望的关键发现进行了广泛概述。

相似文献

1
Neuroimaging and Anxiety: the Neural Substrates of Pathological and Non-pathological Anxiety.神经影像学与焦虑:病理性和非病理性焦虑的神经基础
Curr Psychiatry Rep. 2015 Jun;17(6):49. doi: 10.1007/s11920-015-0586-9.
2
Anxiety symptoms are associated with smaller insular and orbitofrontal cortex volumes in late-life depression.焦虑症状与老年期抑郁症患者的岛叶和眶额皮质体积较小有关。
J Affect Disord. 2019 Sep 1;256:282-287. doi: 10.1016/j.jad.2019.05.066. Epub 2019 May 29.
3
Cognitive and neural models of threat appraisal in psychosis: A theoretical integration.精神病患者威胁评估的认知和神经模型:理论整合。
Psychiatry Res. 2016 May 30;239:131-8. doi: 10.1016/j.psychres.2016.03.016. Epub 2016 Mar 9.
4
[An update on the conceptual and classification issues of anxiety, its neuroanatomy and problems of anxiolytic drug discovery].[焦虑症的概念与分类问题、神经解剖学及抗焦虑药物研发问题的最新进展]
Neuropsychopharmacol Hung. 2015 Jun;17(2):69-80.
5
Neural substrates of childhood anxiety disorders: a review of neuroimaging findings.儿童焦虑障碍的神经基础:神经影像学研究进展综述。
Child Adolesc Psychiatr Clin N Am. 2012 Jul;21(3):501-25. doi: 10.1016/j.chc.2012.05.002. Epub 2012 Jun 4.
6
Neurostructural abnormalities in pediatric anxiety disorders.儿童焦虑症中的神经结构异常。
J Anxiety Disord. 2015 May;32:81-8. doi: 10.1016/j.janxdis.2015.03.004. Epub 2015 Mar 17.
7
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders.腹内侧前额叶皮质的功能解剖:对心境和焦虑障碍的影响。
Mol Psychiatry. 2012 Feb;17(2):132-41. doi: 10.1038/mp.2011.88. Epub 2011 Jul 26.
8
The relation of worry to prefrontal cortex volume in older adults with and without generalized anxiety disorder.有和没有广泛性焦虑症的老年人中担忧与前额叶皮质体积的关系。
Psychiatry Res. 2009 Aug 30;173(2):121-7. doi: 10.1016/j.pscychresns.2008.09.010. Epub 2009 Jun 25.
9
On a continuum to anxiety disorders: Adolescents at parental risk for anxiety show smaller rostral anterior cingulate cortex and insula thickness.从焦虑障碍连续谱看:父母有焦虑风险的青少年表现出前扣带皮层和脑岛前部较小的头侧。
J Affect Disord. 2019 Apr 1;248:34-41. doi: 10.1016/j.jad.2019.01.028. Epub 2019 Jan 28.
10
Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems: A Meta-analysis.有行为问题的青少年的皮质和皮质下灰质体积:一项荟萃分析。
JAMA Psychiatry. 2016 Jan;73(1):64-72. doi: 10.1001/jamapsychiatry.2015.2423.

引用本文的文献

1
Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression: A Randomized Clinical Trial.个性化高清经颅直流电刺激治疗抑郁症:一项随机临床试验。
JAMA Netw Open. 2025 Sep 2;8(9):e2531189. doi: 10.1001/jamanetworkopen.2025.31189.
2
Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a H-magnetic resonance spectroscopy meta-analysis.焦虑症中皮质含胆碱化合物的跨诊断减少:一项氢磁共振波谱荟萃分析
Mol Psychiatry. 2025 Sep 5. doi: 10.1038/s41380-025-03206-7.
3
Deep brain stimulation modulates directional limbic connectivity in major depressive disorder.

本文引用的文献

1
Novelty-facilitated extinction: providing a novel outcome in place of an expected threat diminishes recovery of defensive responses.新奇促进消退:提供一种新的结果以替代预期威胁会减少防御反应的恢复。
Biol Psychiatry. 2015 Aug 1;78(3):203-9. doi: 10.1016/j.biopsych.2014.12.008. Epub 2014 Dec 16.
2
Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder.广泛性社交焦虑障碍患者在间接和直接加工情绪面孔过程中前扣带回皮质和脑岛的反应
Biol Mood Anxiety Disord. 2013 Apr 2;3:7. doi: 10.1186/2045-5380-3-7. eCollection 2013.
3
Recent advances in the brain imaging of social anxiety disorder.
深部脑刺激调节重度抑郁症中的定向边缘系统连接。
Psychol Med. 2025 Aug 8;55:e231. doi: 10.1017/S0033291725100767.
4
Correlates and Brain Substrates of Happiness in Community-Dwelling Older Adults in India.印度社区老年人幸福感的相关因素和大脑基础。
J Gerontol B Psychol Sci Soc Sci. 2024 Dec 1;79(12). doi: 10.1093/geronb/gbae174.
5
Immediate and long-term efficacy of transcranial direct current stimulation (tCDS) in obsessive-compulsive disorder, posttraumatic stress disorder and anxiety disorders: a systematic review and meta-analysis.经颅直流电刺激(tDCS)治疗强迫症、创伤后应激障碍和焦虑症的即时和长期疗效:系统评价和荟萃分析。
Transl Psychiatry. 2024 Aug 25;14(1):343. doi: 10.1038/s41398-024-03053-0.
6
A widespread electrical brain network encodes anxiety in health and depressive states.一个广泛的脑电网络在健康和抑郁状态下对焦虑进行编码。
bioRxiv. 2024 Jun 30:2024.06.26.600900. doi: 10.1101/2024.06.26.600900.
7
Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor.在作为应激源的尼古丁引起的焦虑和工作记忆损伤相关行为效应中,内源性大麻素/内香草素(TRPV1)系统和表观遗传过程的相互关联涉及。
Addict Biol. 2024 Jul;29(7). doi: 10.1111/adb.13421.
8
How does the macroenvironment influence brain and behaviour-a review of current status and future perspectives.宏观环境如何影响大脑和行为——当前状况和未来展望的综述。
Mol Psychiatry. 2024 Oct;29(10):3268-3286. doi: 10.1038/s41380-024-02557-x. Epub 2024 Apr 24.
9
How does the macroenvironment influence brain and behaviour - a review of current status and future perspectives.宏观环境如何影响大脑与行为——现状与未来展望综述
medRxiv. 2023 Oct 10:2023.10.09.23296785. doi: 10.1101/2023.10.09.23296785.
10
Altered Fractional Amplitude of Low-Frequency Fluctuation in Anxious Parkinson's Disease.焦虑型帕金森病低频振荡分数振幅的改变
Brain Sci. 2023 Jan 2;13(1):87. doi: 10.3390/brainsci13010087.
社交焦虑障碍脑成像的最新进展。
Hum Psychopharmacol. 2013 Jan;28(1):102-5. doi: 10.1002/hup.2281. Epub 2012 Dec 13.
4
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder.在广泛性社交恐惧症、广泛性焦虑症和共患广泛性社交恐惧症/广泛性焦虑症中,情绪调节和自上而下的注意力控制时背侧前扣带皮层活动减少。
Biol Psychiatry. 2012 Sep 15;72(6):476-82. doi: 10.1016/j.biopsych.2012.04.013. Epub 2012 May 15.
5
Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.静息杏仁核和内侧前额叶代谢可预测恐惧消退回路的功能激活。
Am J Psychiatry. 2012 Apr;169(4):415-23. doi: 10.1176/appi.ajp.2011.10121780.
6
Functional magnetic resonance imaging correlates of emotional word encoding and recognition in depression and anxiety disorders.功能性磁共振成像在抑郁和焦虑障碍情绪词编码和识别中的相关性。
Biol Psychiatry. 2012 Apr 1;71(7):593-602. doi: 10.1016/j.biopsych.2011.11.016. Epub 2011 Dec 28.
7
Fear extinction as a model for translational neuroscience: ten years of progress.恐惧消除作为转化神经科学的模型:十年的进展。
Annu Rev Psychol. 2012;63:129-51. doi: 10.1146/annurev.psych.121208.131631.
8
Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: a systematic review.焦虑障碍和重度抑郁症中心理治疗与药物治疗对大脑功能和形态改变影响的差异:系统评价。
Neurosci Biobehav Rev. 2012 Jan;36(1):626-44. doi: 10.1016/j.neubiorev.2011.09.004. Epub 2011 Sep 24.
9
Regional homogeneity changes in social anxiety disorder: a resting-state fMRI study.社交焦虑障碍的局部一致性变化:一项静息态 fMRI 研究。
Psychiatry Res. 2011 Oct 31;194(1):47-53. doi: 10.1016/j.pscychresns.2011.01.010. Epub 2011 Aug 9.
10
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders.腹内侧前额叶皮质的功能解剖:对心境和焦虑障碍的影响。
Mol Psychiatry. 2012 Feb;17(2):132-41. doi: 10.1038/mp.2011.88. Epub 2011 Jul 26.