Sauler Maor, Bucala Richard, Lee Patty J
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut; and.
Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L1-10. doi: 10.1152/ajplung.00339.2014. Epub 2015 May 8.
The prevalence of many common respiratory disorders, including pneumonia, chronic obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is known of the host factors that may predispose individuals to such diseases. Macrophage migration inhibitory factor (MIF) is a potent upstream regulator of the immune system. MIF is encoded by variant alleles that occur commonly in the population. In addition to its role as a proinflammatory cytokine, a growing body of literature demonstrates that MIF influences diverse molecular processes important for the maintenance of cellular homeostasis and may influence the incidence or clinical manifestations of a variety of chronic lung diseases. This review highlights the biological properties of MIF and its implication in age-related lung disease.
包括肺炎、慢性阻塞性肺疾病、肺纤维化和肺癌在内的许多常见呼吸系统疾病的患病率会随着年龄的增长而升高。对于可能使个体易患此类疾病的宿主因素，我们知之甚少。巨噬细胞移动抑制因子（MIF）是免疫系统强有力的上游调节因子。MIF由人群中常见的变异等位基因编码。除了作为促炎细胞因子的作用外，越来越多的文献表明，MIF会影响对维持细胞内稳态很重要的多种分子过程，并且可能影响多种慢性肺病的发病率或临床表现。这篇综述重点介绍了MIF的生物学特性及其在与年龄相关的肺病中的意义。
