Zhu Na, Jacobs David R, Schreiner Pamela J, Launer Lenore J, Whitmer Rachel A, Sidney Stephen, Demerath Ellen, Thomas William, Bouchard Claude, He Ka, Erus Guray, Battapady Harsha, Bryan R Nick
From the Divisions of Epidemiology and Community Health (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota; St. Barnabas Hospital (N.Z.), affiliated with Albert Einstein College of Medicine; Neuroepidemiology Section (L.J.L.), NIA; Kaiser Permanente Division of Research (R.A.W., S.S.); Human Genomics (C.B.), Pennington Biomedical Research Center; School of Public Health (K.H.), Indiana University Bloomington; and Department of Radiology (G.E., H.B., R.N.B.), University of Pennsylvania.
Neurology. 2015 Jun 9;84(23):2347-53. doi: 10.1212/WNL.0000000000001658. Epub 2015 May 8.
We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings.
We studied 565 healthy, middle-aged, black and white men and women in the CARDIA (Coronary Artery Risk Development in Young Adults) Study. The fitness measure was symptom-limited maximal treadmill test duration (Maxdur); brain MRI was measured 5 years later. Brain MRI measures were analyzed as means and as proportions below the 15th percentile (above the 85th percentile for white matter abnormal tissue volume).
Per 1-minute-higher Maxdur, the odds ratio for having less whole brain volume was 0.85 (p = 0.04) and for having low white matter integrity was 0.80 (p = 0.02), adjusted for age, race, sex, clinic, body mass index, smoking, alcohol, diet, physical activity, education, blood pressure, diabetes, total cholesterol, and lung function (plus intracranial volume for white matter integrity). No significant associations were observed between Maxdur and abnormal tissue volume or blood flow in white matter. Findings were similar for associations with continuous brain MRI measures.
Greater physical fitness was associated with more brain volume and greater white matter integrity measured 5 years later in middle-aged adults.
我们假设更高的心肺适能与脑部磁共振成像（MRI）出现不良结果的较低几率相关。
我们在CARDIA（青年成人冠状动脉风险发展）研究中对565名健康的中年黑人和白人男性及女性进行了研究。适能测量指标为症状限制的最大跑步机测试持续时间（Maxdur）；5年后进行脑部MRI检查。脑部MRI测量结果以平均值以及低于第15百分位数（白质异常组织体积高于第85百分位数）的比例进行分析。
在对年龄、种族、性别、诊所、体重指数、吸烟、饮酒、饮食、身体活动、教育程度、血压、糖尿病、总胆固醇和肺功能（白质完整性分析时加上颅内体积）进行校正后，Maxdur每增加1分钟，全脑体积较小的比值比为0.85（p = 0.04），白质完整性较低的比值比为0.80（p = 0.02）。未观察到Maxdur与白质异常组织体积或血流之间存在显著关联。与连续性脑部MRI测量指标的关联结果相似。
在中年成年人中，更高的体能与5年后更大的脑容量和更高的白质完整性相关。
