Department of Gynaecology and Obstetrics.
Department of Internal Medicine II (Oncology, Haematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen, Germany and.
Rheumatology (Oxford). 2015 Sep;54(9):1709-12. doi: 10.1093/rheumatology/kev124. Epub 2015 May 8.
Recent publications have shown a negative influence of SLE on female ovarian reserve. Other authors have not found a significant impact of Crohn's disease or early RA on anti-Müllerian hormone (AMH) levels. This study aimed to investigate the potential effect of Behçet's disease (BD), RA and SpA on ovarian reserve as reflected by serum AMH levels.
Serum samples from 33 RA, 32 SpA and 30 BD patients without previous cytotoxic treatment were analysed and compared with age-matched, healthy controls. AMH was quantified using a standard ELISA with a standard value of 1-8 ng/ml; values <1 ng/ml defined a reduced ovarian reserve.
Median age was 26, 28.5 and 33 years and median disease duration was 6, 5.9 and 7 years for RA, SpA and BD patients, respectively. Compared with healthy controls, patients had significantly reduced AMH levels, with a median value for RA of 1.8 ng/ml (control 2.4 ng/ml; P = 0.009), for SpA of 1.5 ng/ml (control 2.3 ng/ml; P = 0.013) and for BD of 1.1 ng/ml (control 1.9 ng/ml; P = 0.007). HLA-B27 had a negative influence on ovarian reserve in SpA patients, whereas other serological parameters did not in the other diseases.
This is the first study to show a reduced ovarian reserve in patients with RA, SpA or BD. Together with our findings in SLE, we conclude a negative influence of chronic rheumatic diseases on ovarian reserve.
最近的出版物表明，SLE 对女性卵巢储备有负面影响。其他作者并未发现克罗恩病或早期 RA 对抗缪勒管激素（AMH）水平有显著影响。本研究旨在探讨贝赫切特病（BD）、RA 和 SpA 对卵巢储备的潜在影响，反映在血清 AMH 水平上。
分析了 33 例 RA、32 例 SpA 和 30 例无先前细胞毒性治疗的 BD 患者的血清样本，并与年龄匹配的健康对照组进行比较。使用标准 ELISA 定量 AMH，标准值为 1-8ng/ml；<1ng/ml 的值定义为卵巢储备减少。
RA、SpA 和 BD 患者的中位年龄分别为 26、28.5 和 33 岁，中位疾病病程分别为 6、5.9 和 7 年。与健康对照组相比，患者的 AMH 水平显著降低，RA 患者的中位数为 1.8ng/ml（对照组为 2.4ng/ml；P=0.009），SpA 患者为 1.5ng/ml（对照组为 2.3ng/ml；P=0.013），BD 患者为 1.1ng/ml（对照组为 1.9ng/ml；P=0.007）。HLA-B27 对 SpA 患者的卵巢储备有负面影响，而其他血清学参数在其他疾病中则没有。
这是第一项显示 RA、SpA 或 BD 患者卵巢储备减少的研究。结合我们在 SLE 中的发现，我们得出结论，慢性风湿性疾病对卵巢储备有负面影响。
