Department of Internal Medicine - Rheumatology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Department of Obstetrics and Gynecology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Int J Rheum Dis. 2017 Dec;20(12):2070-2076. doi: 10.1111/1756-185X.12693. Epub 2015 Jul 14.
To compare ovarian reserve with anti-müllerian hormone (AMH) levels, antral follicle counts (AFCs) and ovarian volume in patients with Behçet's disease (BD) and healthy subjects.
This study included 35 women with BD (mean age: 34.4 ± 5.3 years) and 35 healthy controls (mean age: 34.1 ± 6.0 years). Venous blood samples collected from groups on menstrual cycle Days 2-4 were analyzed using the enzyme-linked immunosorbent assay to measure follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E ), prolactin (PRL) and AMH levels. The AFCs and ovarian volumes were estimated by ultrasonography on the same day. The body mass index (BMI), duration and severity of the disease, medications, and number of children were recorded.
There was no statistically significant difference in the mean age, median gravida/para/abortus and the number of live births and mean BMI between the patient and control groups (P > 0.05). No statistically significant difference in the median FSH, LH, E2, PRL levels, right and left ovarian volumes, and right and left ovarian AFCs was observed among the patients and the controls (P > 0.05). There was no statistically significant difference in the mean AMH levels (P = 0.468). Bonferroni correction showed no statistically significant correlation between AMH levels and age, BMI, FSH, LH, E2, PRL levels, right and left ovarian AFCs, right and left ovarian volume (P > 0.025) among the controls and the patients.
Our study results suggest that ovarian reserve is preserved in patients with BD. In addition, AMH levels of the BD patients were similar to levels of healthy subjects.
比较抗苗勒管激素（AMH）水平、窦卵泡计数（AFC）和卵巢体积在白塞病（BD）患者和健康对照者中的差异。
本研究纳入 35 例 BD 患者（平均年龄：34.4±5.3 岁）和 35 例健康对照者（平均年龄：34.1±6.0 岁）。两组在月经周期第 2-4 天采集静脉血，采用酶联免疫吸附试验检测卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、催乳素（PRL）和 AMH 水平。同日采用超声检查估计 AFC 和卵巢体积。记录体重指数（BMI）、疾病持续时间和严重程度、用药情况和活产数。
患者组与对照组的平均年龄、中位孕次/产次/流产次数和活产数以及平均 BMI 比较，差异均无统计学意义（P＞0.05）。两组间 FSH、LH、E2、PRL 水平、左右侧卵巢体积和左右侧卵巢 AFC 中位数比较，差异均无统计学意义（P＞0.05）。两组 AMH 水平的均值比较，差异也无统计学意义（P=0.468）。Bonferroni 校正后，对照组和患者组 AMH 水平与年龄、BMI、FSH、LH、E2、PRL 水平、左右侧卵巢 AFC、左右侧卵巢体积均无相关性（P＞0.025）。
本研究结果提示 BD 患者卵巢储备功能正常，且 AMH 水平与健康对照者相似。
