Wrighton Paul J, Kiessling Laura L
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA.
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53792, USA.
Cell Stem Cell. 2015 May 7;16(5):453-4. doi: 10.1016/j.stem.2015.04.018.
3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.
能够重现器官功能的3D器官芽在再生医学和个性化医疗中有无数应用。在此，武部等人（2015年）描述了一种生成器官芽的通用方法，证明机械敏感性间充质干细胞可驱动异型细胞混合物凝聚，从而从多种器官生成芽体。
